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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2021; 13(7): 737-752
Published online Jul 26, 2021. doi: 10.4252/wjsc.v13.i7.737
Roles of mitochondrial unfolded protein response in mammalian stem cells
Li-Fang Gu, Jia-Qi Chen, Qing-Yin Lin, Yan-Zhou Yang
Li-Fang Gu, Jia-Qi Chen, Qing-Yin Lin, Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, Ningxia Hui Autonomous Region, China
Yan-Zhou Yang, Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750001, Ningxia Hui Autonomous Region, China,
Author contributions: Gu LF mainly wrote the manuscript; Chen JQ and Lin QY were involved in writing part of the manuscript and preparing the figure; Yang YZ supervised, designed, and revised the manuscript.
Supported by the Key Projects of Natural Science Foundation of Ningxia, No. 2020AAC02020; and the Funds of Ningxia Medical University, No. XY201808.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Zhou Yang, PhD, Professor, Key Laboratory of Fertility Preservation and Maintenance, Ministry of Education, Key Laboratory of Reproduction and Genetics in Ningxia, Department of Histology and Embryology, School of Basic Medicine, Ningxia Medical University, No. 1160 Shengli Street, Yinchuan 750001, Ningxia Hui Autonomous Region, China. alnord820119@163.com
Received: February 7, 2021
Peer-review started: February 7, 2021
First decision: May 5, 2021
Revised: May 13, 2021
Accepted: June 15, 2021
Article in press: June 15, 2021
Published online: July 26, 2021
Core Tip

Core Tip: Mitochondrial unfolded protein response (UPRmt) is a newly discovered equilibrium stress mechanism of mitochondria in the stressed cells to maintain the stressed proteins. Stem cells are a group of cells that have an infinite or eternal ability to self-renew and affect cell differentiation, aging, cancer, etc. Here we discuss the potential significance of UPRmt in stem cells, with an aim to provide a new theoretical basis and therapeutic target for cell differentiation, senescence, and some diseases.