Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2021; 13(5): 416-438
Published online May 26, 2021. doi: 10.4252/wjsc.v13.i5.416
Low complexity domains, condensates, and stem cell pluripotency
Munender Vodnala, Eun-Bee Choi, Yick W Fong
Munender Vodnala, Eun-Bee Choi, Yick W Fong, Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States
Yick W Fong, Harvard Stem Cell Institute, Cambridge, MA 02138, United States
Author contributions: Fong YW, Vodnala M and Choi EB wrote and edited the manuscript; Vodnala M made the figures and table; all authors have read and approved the final manuscript.
Supported by National Institute of Health, No. R01HL125527.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yick W Fong, PhD, Assistant Professor, Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, United States. yfong@bwh.harvard.edu
Received: March 10, 2021
Peer-review started: March 10, 2021
First decision: April 19, 2021
Revised: April 20, 2021
Accepted: April 28, 2021
Article in press: April 28, 2021
Published online: May 26, 2021
Core Tip

Core Tip: This review article discusses recent findings regarding the role of low-complexity domain proteins and phase separation in regulating key cellular processes in embryonic stem cells, including transcriptional activation and repression, cellular signaling integration, DNA damage response, and DNA repair.