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World J Stem Cells. Feb 26, 2021; 13(2): 139-154
Published online Feb 26, 2021. doi: 10.4252/wjsc.v13.i2.139
Targeting mesenchymal stem cell therapy for severe pneumonia patients
Guy Lam, Yuan Zhou, Jia-Xian Wang, Yat-Ping Tsui
Guy Lam, School of Biomedical Sciences, University of Hong Kong, Hong Kong 999077, China
Yuan Zhou, Jia-Xian Wang, Yat-Ping Tsui, Research and Development, Help Therapeutics Co. Ltd., Nanjing 211100, Jiangsu Province, China
Author contributions: Lam G contributed to conception, data analysis and interpretation, manuscript writing and final manuscript approval; Tsui YP contributed to conception, financial support, data analysis and interpretation, manuscript writing and final manuscript approval; all authors read and approved the final manuscript.
Supported by the Project Contract for Technical Innovation Project for Small and Medium-sized Science and Technology Enterprises in Jiangning District, No. 2020JSCX0563.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yat-Ping Tsui, PhD, Director, Research & Development, Help Therapeutics Co. Ltd., No. 568 Longmian Avenue, Jiangning District, Nanjing 211100, Jiangsu Province, China. tsuiypa@helptx.com.cn
Received: July 17, 2020
Peer-review started: July 17, 2020
First decision: October 21, 2020
Revised: December 3, 2020
Accepted: December 27, 2020
Article in press: December 27, 2020
Published online: February 26, 2021
Processing time: 200 Days and 0.4 Hours
Core Tip

Core Tip: This article reviews the therapeutic potential and amplifiable merits of mesenchymal stem cells (MSCs) established over the past decade and summarize pioneering clinical progress of MSC-based strategies to treat lung diseases considering the current demands of the pandemic and future prospects.