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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2021; 13(1): 49-63
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.49
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.49
Mesenchymal stem cell-derived small extracellular vesicles in the treatment of human diseases: Progress and prospect
Jie Shi, Yu-Chen Zhao, Hao-Jun Fan, Shi-Ke Hou, Xiao-Qin Guo, Lu Sang, Qi Lv, Institute of Disaster Medicine, Tianjin University, Tianjin 300072, China
Jie Shi, Yu-Chen Zhao, Hao-Jun Fan, Shi-Ke Hou, Xiao-Qin Guo, Lu Sang, Qi Lv, Department of Biomaterials and Regenrative Medicine, Tianjin Key Laboratory of Disaster Medicine Technology, Tianjin 300072, China
Zhi-Fang Niu, General Hospital, Tianjin Medical University, Tianjin 300052, China
Author contributions: Shi J, Zhao YC, Niu ZF, and Lv Q wrote the paper; Guo XQ and Sang L collected the data; Hou SK, Fan HJ, and Lv Q revised the paper; Shi J, Zhao YC, and Niu ZF contribute equally to this work.
Supported by National Natural Science Foundation of China , No. 81971878 ; Opening Project of Military Logistics , No. BLB19J006 ; and Tianjin University Independent Innovation Fund , No. 2020XRG-0027, No. 2020XYF-0041, and No. 2020XZY-0086.
Conflict-of-interest statement: The authors do not have any conflict of interests to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Qi Lv, MD, PhD, Academic Research, Associate Professor, Institute of Disaster Medicine, Tianjin University, No. 92 Weijin Road, Nankai District, Tianjin 300072, China. lvqi68@163.com
Received: August 17, 2020
Peer-review started: August 17, 2020
First decision: October 21, 2020
Revised: November 2, 2020
Accepted: November 11, 2020
Article in press: November 11, 2020
Published online: January 26, 2021
Peer-review started: August 17, 2020
First decision: October 21, 2020
Revised: November 2, 2020
Accepted: November 11, 2020
Article in press: November 11, 2020
Published online: January 26, 2021
Core Tip
Core Tip: Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) have drawn much attention as attractive agents for treating multiple diseases. The properties of MSC-sEVs include low immunogenicity and increased stability in circulation. Moreover, emerging evidence has shown that MSC-sEVs have equal or even better treatment efficacies than MSCs in many kinds of disease.