Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2020; 12(8): 879-896
Published online Aug 26, 2020. doi: 10.4252/wjsc.v12.i8.879
Role of mesenchymal stem cell derived extracellular vesicles in autoimmunity: A systematic review
Jing-Hua Wang, Xiao-Ling Liu, Jian-Mei Sun, Jing-Han Yang, Dong-Hua Xu, Shu-Shan Yan
Jing-Hua Wang, Jing-Han Yang, Clinical Medicine College, Weifang Medical University, Weifang 261000, Shandong Province, China
Xiao-Ling Liu, Department of Emergency Medicine, Yantai Shan Hospital, Yantai 264001, Shandong Province, China
Jian-Mei Sun, Department of Chemistry, School of Applied Chemistry, Food and Drug, Weifang Engineering Vocational College, Qingzhou 262500, Shandong Province, China
Dong-Hua Xu, Department of Rheumatology of the First Affiliated Hospital, Weifang Medical University, Central Laboratory of the First Affiliated Hospital, Weifang 261000, Shandong Province, China
Shu-Shan Yan, Department of Gastrointestinal and Anal Diseases Surgery of the Affiliated Hospital, Weifang Medical University, Weifang 261000, Shandong Province, China
Author contributions: All authors equally contributed to this work with regard to conception and design of the study, literature analysis, manuscript drafting, critical revision, and editing, and approval of the final version.
Supported by the Shandong Natural Science Foundation, No. ZR2019QH012.
Conflict-of-interest statement: The authors have no potential conflicts of interests to declare.
PRISMA 2009 Checklist statement: The guidelines of the PRISMA 2009 statement have been adopted.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Shu-Shan Yan, MD, Doctor, Department of Gastrointestinal and Anal Diseases Surgery, The Affiliated Hospital, Weifang Medical University, Weifang 261000, Shandong Province, China.
Received: March 4, 2020
Peer-review started: March 4, 2020
First decision: April 25, 2020
Revised: July 2, 2020
Accepted: July 19, 2020
Article in press: July 19, 2020
Published online: August 26, 2020
Core Tip

Core tip: Mesenchymal stem cells (MSCs) have been reported to possess immunomodulatory effects on autoimmune responses. MSCs can mediate intercellular communications by releasing extracellular vesicles (EVs), which deliver functional molecules to targeted cells. MSC derived EVs (MSC-EVs) exert immunomodulatory effects on many immune cells. A large number of studies have suggested that MSC-EVs and the encapsulated bioactive molecules are potential targets for autoimmune disease, cancer, and other diseases. However, there is still a long way for investigating the molecular mechanism of MSC-EVs in autoimmunity. This review will focus on the immunomodulatory function and underlying mechanism of MSC-EVs in autoimmunity related diseases.