Published online Aug 26, 2020. doi: 10.4252/wjsc.v12.i8.787
Peer-review started: February 28, 2020
First decision: April 2, 2020
Revised: April 10, 2020
Accepted: July 26, 2020
Article in press: July 26, 2020
Published online: August 26, 2020
Core tip: Alzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. The results from recent preclinical studies regarding stem cell-based therapies are promising. Human clinical trials are now underway. However, a number of questions remain to be answered prior to safe and effective clinical translation. This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.