John Underwood, Departments of Internal Medicine and Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Mahvish Rahim, Karen E Pollok, Kent A Robertson, W Scott Goebel, Kerry M Hege, Department of Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Carijo West, Rebecca Britton, Elaine Skipworth, Vicki Graves, Steven Sexton, Hillary Harris, Dave Schwering, Cellular Therapy Laboratory, Indiana University Health, Indianapolis, IN 46202, United States
Anthony Sinn, Karen E Pollok, Department of Pediatrics, Herman B Wells Center for Pediatric Research, In Vivo Therapeutics Core and Angio Biocore Shared Resource Facilities for the Indiana University Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Author contributions: Skipworth E, Pollok KE, Robertson KA, Goebel WS and Hege KM designed and coordinated the study; West C, Britton R, Graves V, Sexton S, Harris H, Schwering D, Sinn A, Goebel WS and Hege KM performed the experiments, acquired and analyzed data; Underwood J, Rahim M, West C, Britton R, Graves V, Sexton S, Harris H, Schwering D, Pollok KE, Robertson KA, Goebel WS and Hege KM interpreted the data; Underwood J, Rahim M, Goebel WS and Hege KM wrote the manuscript; all authors approved the final version of the manuscript.
Supported by a pilot grant from the Indiana University Center of Excellence in Molecular Hematology, NIDDK, No. P30DK090948 (to Hege KM and Goebel WS); the NIH/NCI Cancer Center, No. P30CA082709 awarded to the Indiana University Simon Comprehensive Cancer Center (to Sinn A and Pollok KE).
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Indiana University School of Medicine.
Institutional animal care and use committee statement: All animal experiments were performed under supervision of the In Vivo Therapeutics Core using procedures approved by the Indiana University School of Medicine Institutional Animal Care and Use Committee (protocol 0000002985).
Conflict-of-interest statement: Goebel WS receives fees as a consulting medical director for Cook Regentec, LLC, and serves as medical director for Ossium Health, Inc. All other authors report no potential conflicts of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: W Scott Goebel, MD, PhD, Medical Director of the Cellular Therapy Laboratory, Associate Professor of Clinical Pediatrics, Division of Pediatric Hematology/Oncology, Indiana University School of Medicine, Room 2626, 705 Riley Hospital Drive, Indianapolis, IN 46202, United States. email@example.com
Received: February 28, 2020
Peer-review started: February 28, 2020
First decision: April 2, 2020
Revised: April 14, 2020
Accepted: April 28, 2020
Article in press: April 28, 2020
Published online: May 26, 2020