Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.445
Peer-review started: February 22, 2019
First decision: April 16, 2019
Revised: April 19, 2019
Accepted: June 20, 2019
Article in press: June 20, 2019
Published online: August 26, 2019
Core tip: Ischemic heart disease and resulting heart failure remain a major public health problem worldwide in spite of therapeutic progresses. Almost two decades ago, stem cell-based therapy appeared as a promising method to stimulate cardiac regeneration. Based on the main findings and challenges faced during clinical trials within this timeframe, a number of consensus and position papers have been issued by key opinion leaders, with the specific aim to empower cell-based cardiac repair and regeneration in patients with the aforesaid maladies.