Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2019; 11(8): 445-451
Published online Aug 26, 2019. doi: 10.4252/wjsc.v11.i8.445
Moving forward on the pathway of cell-based therapies in ischemic heart disease and heart failure – time for new recommendations?
Miruna Mihaela Micheu
Miruna Mihaela Micheu, Department of Cardiology, Clinical Emergency Hospital of Bucharest, Bucharest 014461, Romania
Author contributions: Micheu MM conceived the study and wrote the manuscript.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Miruna Mihaela Micheu, MD, PhD, Doctor, Department of Cardiology, Clinical Emergency Hospital of Bucharest, Floreasca Street 8, Bucharest 014452, Romania. mirunamicheu@yahoo.com
Telephone: +40-72-2451755
Received: February 21, 2019
Peer-review started: February 22, 2019
First decision: April 16, 2019
Revised: April 19, 2019
Accepted: June 20, 2019
Article in press: June 20, 2019
Published online: August 26, 2019
Core Tip

Core tip: Ischemic heart disease and resulting heart failure remain a major public health problem worldwide in spite of therapeutic progresses. Almost two decades ago, stem cell-based therapy appeared as a promising method to stimulate cardiac regeneration. Based on the main findings and challenges faced during clinical trials within this timeframe, a number of consensus and position papers have been issued by key opinion leaders, with the specific aim to empower cell-based cardiac repair and regeneration in patients with the aforesaid maladies.