Dysfunctional stem and progenitor cells impair fracture healing with age
Diane R Wagner, Sonali Karnik, Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, United States
Zachary J Gunderson, Todd O McKinley, Melissa A Kacena, Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Jeffery J Nielsen, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, United States
Alanna Fennimore, M Terry Loghmani, Department of Physical Therapy, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, United States
Hunter J Promer, Jonathan W Lowery, Division of Biomedical Science, Marian University College of Osteopathic Medicine, Indianapolis, IN 46222, United States
Philip S Low, Department of Chemistry, Purdue University, West Lafayette, IN 47907 United States
Melissa A Kacena, Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, United States
Matthias Clauss, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States
Jiliang Li, Department of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, United States
Author contributions: All authors contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and approval of the final version.
Supported by in part of the following grants: Indiana University Collaborative Research Grant; Indiana Clinical and Translational Sciences Institute, No. NIH UL1TR001108, No. NIH R01 AR069657, No. NIH R01 AR060863 and No. NIH R01 AG060621. This material is also the result of work supported with resources and the use of facilities at the Richard L. Roudebush VA Medical Center, Indianapolis, IN, VA Merit, No. BX003751; the contents do not represent the views of the U.S. Department of Veterans Affairs or the United States Government.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Diane R Wagner, PhD, Associate Professor, Department of Mechanical and Energy Engineering, Indiana University-Purdue University Indianapolis, 723 W. Michigan St. SL 260, Indianapolis, IN 46220, United States. firstname.lastname@example.org
Telephone: +1-317-2748958 Fax: +1-317-2744567
Received: March 21, 2019
Peer-review started: March 22, 2019
First decision: April 11, 2019
Revised: April 26, 2019
Accepted: June 12, 2019
Article in press: June 12, 2019
Published online: June 26, 2019