Published online Oct 26, 2019. doi: 10.4252/wjsc.v11.i10.764
Peer-review started: March 20, 2019
First decision: April 16, 2019
Revised: May 17, 2019
Accepted: August 27, 2019
Article in press: August 27, 2019
Published online: October 26, 2019
Core tip: Biodegradable and biocompatible polymers, poly(3-hydroxyalkanoates) (PHAs), are actively used for the manufacture of scaffolds that serve as carriers for mesenchymal stem cell growth in tissue engineering. It was shown that PHAs have their own biological activity affecting mesenchymal stem cell growth and differentiation. However, the mechanisms of the biological activity of PHAs remain unclear. In this review, we discuss the possible association of the effects of bacteria-originating PHAs on mesenchymal stem cells with various biological functions of PHAs in bacteria and eukaryotes, including in humans.