Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2018; 10(4): 34-42
Published online Apr 26, 2018. doi: 10.4252/wjsc.v10.i4.34
NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B
Jianbiao Zhou, Jing-Yuan Chooi, Ying Qing Ching, Jessie Yiying Quah, Sabrina Hui-Min Toh, Yvonne Ng, Tuan Zea Tan, Wee-Joo Chng
Jianbiao Zhou, Ying Qing Ching, Jessie Yiying Quah, Sabrina Hui-Min Toh, Yvonne Ng, Tuan Zea Tan, Wee-Joo Chng, Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore
Jianbiao Zhou, Jing-Yuan Chooi, Wee-Joo Chng, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore
Wee-Joo Chng, Department of Hematology-Oncology, National University Cancer Institute, Singapore 119228, Singapore
Author contributions: Zhou J and Chng WJ conceptualized the original idea, designed the experiments and analyzed the data; Zhou J performed the experiments, wrote the paper; Chooi JY, Ching YQ, Quah JY, Toh SHM and Ng Y performed the experiments; Tan TZ conducted the bioinformatics analysis; all authors read and approved the final manuscript.
Supported by the Singapore National Research Foundation and the Ministry of Education under the Research Center of Excellence Program to WJ Chng and NMRC Clinician-Scientist IRG Grant CNIG11nov38 (Zhou J); Chng WJ is also supported by NMRC Clinician Scientist Investigator award; This study is also partially supported by the RNA Biology Center at CSI Singapore, NUS, from funding by the Singapore Ministry of Education’s Tier 3 Grants, No. MOE2014-T3-1-006.
Conflict-of-interest statement: No potential conflicts of interest relevant to this article were reported.
Data sharing statement: The datasets supporting the conclusions of this article are included within the article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jianbiao Zhou, MD, PhD, Senior Scientist, Cancer Science Institute of Singapore, National University of Singapore, 28 Medical Drive, Singapore 117456, Singapore. csizjb@nus.edu.sg
Telephone: +65-6-5161118
Received: March 6, 2018
Peer-review started: March 6, 2018
First decision: March 13, 2018
Revised: March 21, 2018
Accepted: April 10, 2018
Article in press: April 10, 2018
Published online: April 26, 2018
Core Tip

Core tip: In this study, we uncovered that LIN28B is regulated by nuclear factor kappa B (NF-κB) activity on transcriptional level and important for NF-κB-mediated leukemia-stem cell like properties of acute myeloid leukemia cells. NF-κB/LIN28B represents an attractive therapeutic target.