Published online Aug 26, 2015. doi: 10.4252/wjsc.v7.i7.992
Peer-review started: April 24, 2015
First decision: May 13, 2015
Revised: May 29, 2015
Accepted: June 18, 2015
Article in press: June 19, 2015
Published online: August 26, 2015
Stem cell differentiation is regulated by multiple signaling events. Recent technical advances have revealed that differentiated cells can be reprogrammed into stem cells. The signals involved in stem cell programming are of major interest in stem cell research. The signaling mechanisms involved in regulating stem cell reprogramming and differentiation are the subject of intense study in the field of life sciences. In this review, the molecular interactions and signaling pathways related to stem cell differentiation are discussed.
Core tip: Signals in stem cell are regulated both genetically and epigenetically by many molecules. The programming of stem cell signaling is an important aspect of understanding stem cell phenotype transitions and functions. The differentiation process as well as intra- and inter-cellular signaling of stem cells is described in this article. The epigenetic regulation of these cells is also discussed.