Pixley JS, Zanjani ED. In utero transplantation: Disparate ramifications. World J Stem Cells 2013; 5(2): 43-52 [PMID: 23671718 DOI: 10.4252/wjsc.v5.i2.43]
Corresponding Author of This Article
John S Pixley, MD, Rheumatology/Immunology Division, Department of Medicine, VA Sierra Health Care System and the University of Nevada School of Medicine, 735 Kirman Avenue, Reno, NV 89557, United States. jpixley@unr.edu
Research Domain of This Article
Transplantation
Article-Type of This Article
Frontier
Open-Access Policy of This Article
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World J Stem Cells. Apr 26, 2013; 5(2): 43-52 Published online Apr 26, 2013. doi: 10.4252/wjsc.v5.i2.43
In utero transplantation: Disparate ramifications
John S Pixley, Esmail D Zanjani
John S Pixley, Rheumatology/Immunology Division, Department of Medicine, VA Sierra Health Care System and the University of Nevada School of Medicine, Reno, NV 89557, United States
Esmail D Zanjani, Department of Agriculture, Nutrition and Veterinary Science University of Nevada, Reno, NV 89512, United States
Author contributions: Pixley JS wrote the manuscript; Zanjani ED made substantial contributions to design, data acquisition and data interpretation; both authors approved the final version.
Supported by Grant HL53955 from NHLBI, NIH, in part
Correspondence to: John S Pixley, MD, Rheumatology/Immunology Division, Department of Medicine, VA Sierra Health Care System and the University of Nevada School of Medicine, 735 Kirman Avenue, Reno, NV 89557, United States. jpixley@unr.edu
Telephone: +1-775-3281297 Fax: +1-775-3281769
Received: December 3, 2012 Revised: January 7, 2013 Accepted: January 23, 2013 Published online: April 26, 2013
Abstract
In utero stem cell transplantation, which promises treatment for a host of genetic disorders early in gestation before disease effect stems from Ray Owen’s seminal observation that self-tolerance, is acquired during gestation. To date, in utero transplantation (IUT) has proved useful in characterizing the hematopoietic stem cell. Recent observations support its use as an in vivo method to further understanding of self-tolerance. Preclinical development continues for its application as a treatment for childhood hematolymphoid diseases. In addition, IUT may offer therapeutic options in the treatment of diabetes among other diseases. Thus IUT serves as a technique or system important in both a basic and applied format. This review summarizes these findings.
