Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2022; 14(8): 680-683
Published online Aug 26, 2022. doi: 10.4252/wjsc.v14.i8.680
Bone marrow mesenchymal stem cell treatment improves post-stroke cerebral function recovery by regulating gut microbiota in rats
Mohsen Sheykhhasan, Naresh Poondla
Mohsen Sheykhhasan, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan 6517838695, Iran
Naresh Poondla, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States
Author contributions: Sheykhhasan M and Poondla N drafted this letter.
Conflict-of-interest statement: No conflict-of-interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mohsen Sheykhhasan, MSc, PhD, Academic Research, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Shariaty Street, Hamadan 6517838695, Iran. mohsen.sh2009@gmail.com
Received: January 6, 2022
Peer-review started: January 6, 2022
First decision: March 13, 2022
Revised: June 29, 2022
Accepted: August 14, 2022
Article in press: August 14, 2022
Published online: August 26, 2022
Abstract

Early intervention with bone marrow mesenchymal stem cells to change the form and function of the gut microbiota may help rats regain neurological function after a stroke.

Keywords: Ischemic stroke, Bone marrow mesenchymal stem cells, Neurological function, Gut microbiota

Core Tip: Using bone marrow mesenchymal stem cells (BMSCs) as a therapy method may be a successful technique to combat neurological conditions like ischemic stroke. The dysbiosis of the gut microbiota can impact stroke prognosis, according to the gut-brain axis. Zhao et al’s study examined the interaction between BMSCs and the gut flora. Zhao et al’s research showed that the ischemic stroke treatment provided by BMSCs may have an impact on the structure and function of the microbiome.