Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Aug 26, 2021; 13(8): 985-1004
Published online Aug 26, 2021. doi: 10.4252/wjsc.v13.i8.985
Inter-regulatory role of microRNAs in interaction between viruses and stem cells
Afsoon Afshari, Ramin Yaghobi, Ghazal Rezaei
Afsoon Afshari, Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz 7193711351, Iran
Ramin Yaghobi, Ghazal Rezaei, Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz 7193711351, Iran
Author contributions: Afshari A and Yaghobi R wrote the paper; Afshari A, Yaghobi R and Rezaee G performed the data collection.
Supported by the Shiraz University of Medical Science, No. 23203.
Conflict-of-interest statement: Authors declare no conflict of interests for this article
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ramin Yaghobi, PhD, Full Professor, Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Khalili Street, Shiraz 7193711351, Iran. rayaviro@yahoo.com
Received: February 27, 2021
Peer-review started: February 27, 2021
First decision: March 29, 2021
Revised: April 11, 2021
Accepted: July 13, 2021
Article in press: July 13, 2021
Published online: August 26, 2021
Abstract

MicroRNAs (miRNAs) are well known for post-transcriptional regulatory ability over specific mRNA targets. miRNAs exhibit temporal or tissue-specific expression patterns and regulate the cell and tissue developmental pathways. They also have determinative roles in production and differentiation of multiple lineages of stem cells and might have therapeutic advantages. miRNAs are a part of some viruses’ regulatory machinery, not a byproduct. The trace of miRNAs was detected in the genomes of viruses and regulation of cell reprograming and viral pathogenesis. Combination of inter-regulatory systems has been detected for miRNAs during viral infections in stem cells. Contraction between viruses and stem cells may be helpful in therapeutic tactics, pathogenesis, controlling viral infections and defining stem cell developmental strategies that is programmed by miRNAs as a tool. Therefore, in this review we intended to study the inter-regulatory role of miRNAs in the interaction between viruses and stem cells and tried to explain the advantages of miRNA regulatory potentials, which make a new landscape for future studies.

Keywords: MicroRNAs, Viruses, Stem cells, Regulatory

Core Tip: MicroRNAs (miRNAs) are well known for post-transcriptional regulatory ability over specific mRNA targets. In this review we intended to study the inter-regulatory role of miRNAs in the interaction between viruses and stem cells and tried to explain the advantages of miRNA regulatory potentials, which make a new landscape for future studies.