Wang HN, Huang YC, Ni GX. Mechanotransduction of stem cells for tendon repair. World J Stem Cells 2020; 12(9): 952-965 [PMID: 33033557 DOI: 10.4252/wjsc.v12.i9.952]
Corresponding Author of This Article
Guo-Xin Ni, PhD, Professor, School of Sport Medicine and Rehabilitation, Beijing Sport University, No. 48 Xinxi Road, Haidian District, Beijing 100084, China. niguoxin@bsu.edu.cn
Research Domain of This Article
Engineering, Biomedical
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Sep 26, 2020; 12(9): 952-965 Published online Sep 26, 2020. doi: 10.4252/wjsc.v12.i9.952
Mechanotransduction of stem cells for tendon repair
Hao-Nan Wang, Yong-Can Huang, Guo-Xin Ni
Hao-Nan Wang, Guo-Xin Ni, School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China
Yong-Can Huang, Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Yong-Can Huang, National and Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, Guangdong Province, China
Author contributions: Wang HN and Huang YC contributed equally to this manuscript; Wang HN and Huang YC wrote the manuscript; Huang YC and Ni GX edited the manuscript and provided feedback.
Supported byNational Natural Science Foundation of China, No. 81871848 and No. 81702171; and Shenzhen Double Chain Project for Innovation and Development Industry, No. 201806081018272960.
Conflict-of-interest statement: The authors have no conflict of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Guo-Xin Ni, PhD, Professor, School of Sport Medicine and Rehabilitation, Beijing Sport University, No. 48 Xinxi Road, Haidian District, Beijing 100084, China. niguoxin@bsu.edu.cn
Received: April 3, 2020 Peer-review started: April 3, 2020 First decision: April 22, 2020 Revised: May 6, 2020 Accepted: July 19, 2020 Article in press: July 19, 2020 Published online: September 26, 2020
Abstract
Tendon is a mechanosensitive tissue that transmits force from muscle to bone. Physiological loading contributes to maintaining the homeostasis and adaptation of tendon, but aberrant loading may lead to injury or failed repair. It is shown that stem cells respond to mechanical loading and play an essential role in both acute and chronic injuries, as well as in tendon repair. In the process of mechanotransduction, mechanical loading is detected by mechanosensors that regulate cell differentiation and proliferation via several signaling pathways. In order to better understand the stem-cell response to mechanical stimulation and the potential mechanism of the tendon repair process, in this review, we summarize the source and role of endogenous and exogenous stem cells active in tendon repair, describe the mechanical response of stem cells, and finally, highlight the mechanotransduction process and underlying signaling pathways.
Core Tip: Stem cells and mechanical loading are crucial to tendon injuries. In this review, we summarize the sources and roles of endogenous and exogenous stem cells for tendon repair, describe the mechanical response of stem cells, and finally highlight the mechanotransduction process and underlying signaling pathways. The deeper understanding of interactions between stem cells and mechanical loading offers great potential for the development of new therapeutic strategies for tendon repair.
