Review
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2020; 12(7): 545-561
Published online Jul 26, 2020. doi: 10.4252/wjsc.v12.i7.545
Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface
Shi-Cheng Huo, Bing Yue
Shi-Cheng Huo, Bing Yue, Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
Author contributions: The two authors contributed equally to the manuscript.
Supported by Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support, No. 20161423.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Bing Yue, MD, PhD, Chief Doctor, Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, No.145, Shandong Road, Shanghai 200011, China. advbmp2@163.com
Received: February 28, 2020
Peer-review started: February 28, 2020
First decision: April 26, 2020
Revised: May 13, 2020
Accepted: May 29, 2020
Article in press: May 29, 2020
Published online: July 26, 2020
Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) play a critical role in the osseointegration of bone and orthopedic implant. However, osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium’s inherent defects. Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate. Here, we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys. We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration, and discuss recent advances in understanding their role in regenerative medicine. We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.

Keywords: Bone marrow mesenchymal stem cells, Osseointegration, Orthopedic implant, Biofunctionalization

Core tip: Bone marrow-derived mesenchymal stem cells (BMSCs) play a key role in tissue repair after bone and joint injures. The effects of the surface treatment of the orthopedic implants on the osteogenic differentiation of BMSCs are worthy of attention. In this paper, we review recent advances in approaches that promote osseointegration of BMSCs on the surface of orthopedic implants.