Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Apr 26, 2020; 12(4): 266-276
Published online Apr 26, 2020. doi: 10.4252/wjsc.v12.i4.266
Insights of stem cell-based endogenous repair of intervertebral disc degeneration
Yang Liu, Yan Li, Li-Ping Nan, Feng Wang, Shi-Feng Zhou, Xin-Min Feng, Hao Liu, Liang Zhang
Yang Liu, Hao Liu, Department of Orthopedics, West China Hospital of Sichuan University, Chengdu 610000, Sichuan Province, China
Yang Liu, Li-Ping Nan, Feng Wang, Department of Orthopedics, Dalian Medical University, Dalian 116000, Liaoning Province, China
Yan Li, Department of Oncology, The Affiliated Cancer Hospital, School of Medicine, UESTC, Chengdu 610000, Sichuan Province, China
Shi-Feng Zhou, Xin-Min Feng, Liang Zhang, Department of Orthopedics, Clinical Medical College of Yangzhou University, Yangzhou 225000, Jiangsu Province, China
Author contributions: Liu Y and Li Y wrote the paper and contributed equally to this work; Nan LP, Wang F, Zhou SF, and Feng XM collected the data; Zhang L and Liu H are co-corresponding authors.
Supported by National Natural Science Foundation of China, No. 81972136; National Natural Science Foundation for Young Scholars of China, No. 81401830; Guangxi Natural Science Foundation General Project, No. 2018JJA14775; Young Medical Scholars Major Program of Jiangsu Province, No. QNRC2016342; Innovation Team Project of Jiangsu Province, No. CXTDB2017004; and Key Funding Project of Maternal and Child Health Research of Jiangsu Province, No. F201801.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Liang Zhang, MD, PhD, Academic Research, Assistant Professor, Associate Chief Physician, Chief Doctor, Research Scientist, Surgeon, Department of Orthopedics, Clinical Medical College of Yangzhou University, No. 98, Nantong West Road, Yangzhou 225000, Jiangsu Province, China.
Received: February 1, 2020
Peer-review started: February 1, 2020
First decision: March 5, 2020
Revised: March 26, 2020
Accepted: April 4, 2020
Article in press: April 4, 2020
Published online: April 26, 2020

Low back pain has become more prevalent in recent years, causing enormous economic burden for society and government. Common therapies used in clinics including conservative treatment and surgery can only relieve pain. Subsequent cell-based treatment such as mesenchymal stem cell transplantation poses problems such as short duration of therapeutic effect and tumorigenesis. Recently, the discovery and identification of stem cell niche and stem/progenitor cells in intervertebral disc bring increased attention to endogenous repair strategy. Therefore, we review the studies involving endogenous repair strategy and present the characteristics and current status of this treatment. Meanwhile, we also discuss the strategy and perspective of endogenous repair strategy in future.

Keywords: Low back pain, Intervertebral disc degeneration, Stem cell niche, Stem/progenitor cell, Endogenous repair strategy, Stem cell treatment

Core tip: Low back pain has become more prevalent and brought enormous economic burden in recent years. However, therapies including conservative treatment, surgery, and cell-based treatment still have several defects. Endogenous repair is a novel therapeutic strategy for intervertebral disc degenerative disease that draws increased attention. We review the research regarding endogenous repair strategy using stem/progenitor cells as main cell resource, concluding and analyzing the status at present and perspective of endogenous repair strategy in future.