Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2019; 11(6): 322-336
Published online Jun 26, 2019. doi: 10.4252/wjsc.v11.i6.322
Effects of various antimicrobial agents on multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells
Hui Li, Bing Yue
Hui Li, Bing Yue, Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China
Author contributions: The two authors contributed equally to the manuscript.
Supported by National Natural Science Foundation of China, Nos. 81472119 and 81672196; and Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support, No. 20161423.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Bing Yue, MD, PhD, Chief Doctor, Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Shandong Road, Shanghai 200011, China.
Telephone: +86-21-53882199
Received: February 6, 2019
Peer-review started: February 11, 2019
First decision: March 15, 2019
Revised: March 30, 2019
Accepted: May 23, 2019
Article in press: May 23, 2019
Published online: June 26, 2019

Antimicrobial drugs of several classes play an important role in the treatment of bone and joint infections. In addition to fighting pathogenic microorganisms, the effects of drugs on local tissues and cells are also related to the course and prognosis of bone and joint infections. The multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) is essential for tissue repair after local injury, which is directly related to the recovery of bone, cartilage, and medullary adipose tissue. Our previous studies and the literature indicate that certain antimicrobial agents can regulate the differentiation potential of bone marrow-derived MSCs. Here, in order to systematically analyze the effects of various antimicrobial drugs on local tissue regeneration, we comprehensively review the studies on the effects of these drugs on MSC differentiation, and classify them according to the three differentiation directions (osteogenesis, chondrogenesis, and adipogenesis). Our review demonstrates the specific effects of different antimicrobial agents on bone marrow-derived MSCs and the range of concentrations at which they work, and provides a basis for drug selection at different sites of infection.

Keywords: Antimicrobial agents, Bone marrow mesenchymal stem cells, Osteogenesis, Chondrogenesis, Adipogenesis

Core tip: Bone marrow-derived mesenchymal stem cells (MSCs) are essential for tissue repair (bone, cartilage, and medullary adipose tissue) after local bone and joint infection. The effects of various antimicrobial agents on the three types of differentiation potential (osteogenesis, chondrogenesis, and adipogenesis) of bone marrow-derived MSCs are worth noting. Here in this paper, we collect the latest updates on the use of antimicrobial agents to regulate the differentiation of MSCs.