Published online Jun 26, 2019. doi: 10.4252/wjsc.v11.i6.322
Peer-review started: February 11, 2019
First decision: March 15, 2019
Revised: March 30, 2019
Accepted: May 23, 2019
Article in press: May 23, 2019
Published online: June 26, 2019
Antimicrobial drugs of several classes play an important role in the treatment of bone and joint infections. In addition to fighting pathogenic microorganisms, the effects of drugs on local tissues and cells are also related to the course and prognosis of bone and joint infections. The multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) is essential for tissue repair after local injury, which is directly related to the recovery of bone, cartilage, and medullary adipose tissue. Our previous studies and the literature indicate that certain antimicrobial agents can regulate the differentiation potential of bone marrow-derived MSCs. Here, in order to systematically analyze the effects of various antimicrobial drugs on local tissue regeneration, we comprehensively review the studies on the effects of these drugs on MSC differentiation, and classify them according to the three differentiation directions (osteogenesis, chondrogenesis, and adipogenesis). Our review demonstrates the specific effects of different antimicrobial agents on bone marrow-derived MSCs and the range of concentrations at which they work, and provides a basis for drug selection at different sites of infection.
Core tip: Bone marrow-derived mesenchymal stem cells (MSCs) are essential for tissue repair (bone, cartilage, and medullary adipose tissue) after local bone and joint infection. The effects of various antimicrobial agents on the three types of differentiation potential (osteogenesis, chondrogenesis, and adipogenesis) of bone marrow-derived MSCs are worth noting. Here in this paper, we collect the latest updates on the use of antimicrobial agents to regulate the differentiation of MSCs.