Published online Apr 26, 2019. doi: 10.4252/wjsc.v11.i4.212
Peer-review started: January 4, 2019
First decision: January 21, 2019
Revised: January 23, 2019
Accepted: March 12, 2019
Article in press: March 12, 2019
Published online: April 26, 2019
The purpose of regenerative medicine is to restore or enhance the normal function of human cells, tissues, and organs. From a clinical point of view, the use of stem cells is more advantageous than differentiated cells because they can be collected more easily and in larger quantities, their proliferation capacity is more pronounced, they are more resistant in cell culture, their aging is delayed, they are able to form a number of cell lines, and they are able to promote vascularization of tissue carriers. The therapeutic use of stem cells for disease modification, immunomodulation, or regenerative purposes are undoubtedly encouraging, but most studies are still in their early stages, and the clinical results reported are not clear with regard to therapeutic efficacy and potential side effects. Uniform regulation of the clinical application of stem cells is also indispensable for this highly customizable, minimally invasive, individualized therapeutic method to become a successful and safe treatment alternative in many different autoimmune and autoinflammatory disorders.
Core tip: The therapeutic use of stem cells in autoimmune diseases for disease modification, immunomodulation, or regenerative purposes are undoubtedly encouraging. However, the clinical results reported are not clear about therapeutic efficacy and potential side effects. Uniform regulation of the clinical application of stem cells is indispensable.