Cyclooxygenase-2 expression and angiogenesis in colorectal cancer

Table 1 Clinicopathologic characteristics of colorectal cancer with expression of COX-2

Variable	n	COX-2 Positive n(%)	COX-2 Negative n(%)
Sex
Male	73	50(68.5)	23(31.5)
Female	55	37(67.3)	18(32.7)
Age(y)		54 ± 12	56 ± 15
Histological differentiation
Well	26	17(65.4)	9 (34.6)
Moderate	57	40(70.2)	17(29.8)
Poor	45	30(66.7)	15(33.3)
Depth of invasion
T1-T2	81	48(59.3)	33(40.7)
T3-T4	47	39(83.0)	8 (17.0)a
Metastasis
Present	50	42(84.0)	8 (16.0)
Absent	78	45(57.7)	33(42.3)a
Duke's stage
A	37	15(40.5)	22(59.5)
B	41	28(68.3)	13(31.7)
C+D	50	44(88.0)	6 (12.0)a
VEGF expression
Positive	49	40(81.6)	9 (18.4)
Negative	79	47(59.5)	32(40.5)a
MVD (¯x± s)		56 ± 16	43 ± 12a

^aP < 0.05, vs positive.