Study on the classification of chronic gastritis at molecular biological level

doi:10.3748/wjg.v9.i4.836

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 9, Issue 4

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2562)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-16) series, Tables (1-6) series.

Item

Count

PDF

280

HTML

1993

Figures (1-16)

172

Tables (1-6)

117

Sum=2562

Apr 15, 2003 (publication date) through Apr 24, 2024

Times Cited of This Article

Times Cited (4)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Apr 15, 2003; 9(4): 836-842
Published online Apr 15, 2003. doi: 10.3748/wjg.v9.i4.836

Table 1 Degree of inflammatory cell infiltration compared with the degree of decrease of original glands in gastric mucosa n (%)

Group	n	Degree of inflammatory cell infiltration			Degree decrease of glands propria
Group	n	< 1/3	> 1/3 < 2/3	> 2/3	< 1/3	1/3 < 2/3	> 2/3
NC	15
CSG-woS	18	11 (61.1)	6 (33.3)	1 (5.6)	1 (5.6)
CAG-woS	9	5 (55.6)	3 (33.3)	1 (11.1)	5 (55.6)^d	3 (33.3)
F-TwS	56
CSG-wS	68	26 (38.2)^c	32 (47.1)	10 (14.7)
CAG-Ws	64	19 (29.7)^d^f	21 (32.8)	24 (37.5)^d^f	23 (35.9)^d	23 (35.9)	18 (28.1)

Compared with NC group. ^aP < 0.05, ^bP < 0.01; compared with CSG-woS group.

^cP < 0.05,

^dP < 0.01; compared with CAG-woS group. ^eP < 0.05,

^fP < 0.01, Compared with F-wS group, ^gP < 0.05, ^hP < 0.01, Compared with CSG-wS group, ⁱP < 0.05, ^jP < 0.01, In table 2-6, the marks are the same as here.

Table 2 Focal background lesions in non-focal site of gastric mucosa n (%)

Focal lesions	CSG-woS (n = 18)		CAG-woS (n = 9)		CSG-wS (n = 68)		CAG-Ws (n = 64)
Focal lesions	Gastric antrum	Gastric body	Gastric antrum	Gastric body	Gastric antrum	Gastric body	Gastric antrum	Gastric body
Atrophic	1 (5.6)	0 (0.0)	1 (11.1)^a	0 (0.0)	21 (30.9)^bd	11 (16.2)	47 (73.4)^bdj	27 (42.2)^j
inflammatory lesion
IM	4 (22.2)	1 (5.6)	5 (55.6)^b	2 (22.2)^b	27 (39.7)^bc	5 (7.4)^d	59 (92.2)^bdj	13 (20.3)^b
Micro ulcer	1 (5.6)	1 (5.6)	3 (33.3)^b	1 (11.1)^a	11 (16.2)	2 (2.9)^c	28 (43.8)^bdj	9 (14.1)^aj

Table 3 Ultrastructures of gastric mucosa epithelial cell nuclei n (%)

Group	n	Appeararce		Chromatin		Nucleoli
Group	n	Nucleoplasmic ratio > 1	Nuclear lobulation	margination or homogeneity	Perinuclear concentration	hypertrophy or margination	looping
NC	15			1 (6.7)	1 (6.7)
CSG-woS	18	1 ( 5.6)		4 (22.2)^b	1 (5.6)	1 (5.6)	1 (5.6)
CAG-woS	9	2 (22.2)^d	2 (22.2)	7 (77.8)^bd	3 (33.3)^bd	2 (22.2)^d	4 (44.4)^d
F-TwS	56			3 (5.4)^df	3 (5.4)^f	1 (1.8)^f
CSG-wS	68	5 ( 5.7)^f	2 (2.9)^f	7 (10.3)^cf	5 (7.4)^f	2 (2.9)^f	2 (2.9)^f
CAG-Ws	64	20 (31.3)^dj	9 (29.7)^j	33 (51.6)^bdhj	29 (45.3)^dfhj	27 (42.2)^dfhj	14 (21.9)^dgi

Table 4 Mitochondria ultrastructures of gastric mucosa epithelial cells. (x^-± s)

Group	n	Number	Swelling & overgrowth (%)	Matrix-discoloration (%)	Vacuolar degencration (%)	Pyknosis (%)	Crista number	Crista fragmentation & derangement (%)
NC	15	86.5 ± 27.3	3.4 ± 1.6	3.0 ± 1.1	2.9 ± 1.9	1.1 ± 0.8	12.8 ± 3.2	2.2 ± 1.1
CSG-woS	18	85.3 ± 22.2	3.9 ± 1.1	3.9 ± 2.2	3.2 ± 1.2	1.4 ± 0.9	11.4 ± 2.4	3.1 ± 1.3
CAG-woS	9	83.8 ± 17.3	4.4 ± 2.4	4.3 ± 2.9	3.3 ± 1.1	1.7 ± 0.8	11.4 ± 2.1	3.2 ± 1.2
F-TwS	56	83.1 ± 22.8	5.4 ± 2.9^bd	4.4 ± 2.4	2.9 ± 1.8	1.2 ± 0.7	11.2 ± 2.3	3.9 ± 1.2^bc
CSG-wS	68	65.4 ± 21.1^bdfh	7.2 ± 3.8^bdfg	7.9 ± 5.0^bdfh	6.4 ± 4.5^bdfh	1.9 ± 0.9^bch	8.2 ± 3.2^bdfh	5.8 ± 3.1^bdfh
CAG-wS	64	52.2 ± 20.8^bdfhj	10.9 ± 4.5^bdfhj	11.7 ± 8.6^bdfhj	11.6 ± 7.7^bdfhj	3.7 ± 1.1^bdfhj	6.9 ± 3.5^bdfhji	8.9 ± 3.7^bdfhj

Table 5 Gastric mucosa trace elements, cAMP and ³H-TdRLCT (x^-± s)

Group	n	Gastric mucosa				Blood ³H-TdRLCT (Bq/L)
Group	n	Zn (WT%)	Cu (WT%)	cAMP (Pmol/g)	SOD (u/g)	Blood ³H-TdRLCT (Bq/L)
NC	15	4.1 ± 1.0	5.2 ± 0.8	15.9 ± 1.5	170.5 ± 6.1	1079.7 ± 227.4
CSG-woS	18	3.7 ± 1.2	5.1 ± 1.8	15.6 ± 0.9	167.2 ± 5.3	924.5 ± 234.9
CAG-woS	9	3.3 ± 1.0	4.8 ± 0.9	14.9 ± 0.7^a	166.1 ± 4.2^a	887.7 ± 243.6
F-TwS	56	3.5 ± 1.4^a	4.5 ± 1.0^a	15.7 ± 1.4^e	167.9 ± 5.7	932.1 ± 2449.3^a
CSG-wS	68	2.8 ± 1.9^bcg	4.0 ± 1.5^aceg	14.2 ± 1.8^bdeh	163.3 ± 5.6^bdh	867.3 ± 240.5^bc
CAG-wS	64	2.0 ± 1.8^bdfhi	3.4 ± 1.5^bdfhj	13.4 ± 1.8^bdfhi	161.2 ± 4.3^bdfhi	800.9 ± 221.8^bdi

Table 6 Epithelial nuclei and mitochondria Zn, Cu in gastric mucosa (x^-± s)

Group	n	Nuclei			Mitochondria		Serum
Group	n	Zn (AT%)	Cu (AT%)	DNA (IOD)	Zn (AT%)	Cu (AT%)	LPO (umol/L)
NC	15	7.6 ± 0.4	58.4 ± 0.3	12.6 ± 2.7	9.2 ± 0.5	58.3 ± 0.3	2.6 ± 0.6
CSG-woS	18	7.8 ± 0.3	58.6 ± 0.4	13.0 ± 3.1	8.9 ± 0.5	58.2 ± 0.3	2.9 ± 0.4
CAG-woS	9	7.8 ± 0.3^a	58.7 ± 0.3^a	14.3 ± 2.8	8.8 ± 0.4^a	57.5 ± 0.2^bd	3.1 ± 0.4
F-TwS	56	7.9 ± 0.4^a	58.7 ± 0.5^a	13.5 ± 4.6	8.9 ± 0.5^a	58.0 ± 0.3^af	2.9 ± 0.7
CSG-wS	68	8.1 ± 0.5^bdfh	58.9 ± 0.5^bdh	15.2 ± 3.2^bcg	8.6 ± 0.5^bh	57.8 ± 0.3^bdfh	4.2 ± 0.7^bdfh
CAG-Ws	64	8.6 ± 0.4^bdfhj	59.3 ± 0.5^bdfhj	16.5 ± 3.1^bdehi	8.3 ± 0.4^bdfhj	57.5 ± 0.3^bdhj	4.5 ± 0.6^bdfhi

Citation: Yin GY, Zhang WN, He XF, Chen Y, Shen XJ. Study on the classification of chronic gastritis at molecular biological level. World J Gastroenterol 2003; 9(4): 836-842
URL: https://www.wjgnet.com/1007-9327/full/v9/i4/836.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i4.836