Analysis of gene expression profile of pancreatic carcinoma using cDNA microarray

Table 1 Over-expressed genes in pancreatic carcinoma

Accession number	Gene name	Gene function	Ratio value
U06863	Alpha 1 (III) collagen	Extracellular metrix	33.89
X91148	Microsomal triglyceride transfer protein	Microsomal triglyceride transfer	21.89
AF017986	Secreted apoptosis related protein 1 (SARP1)	Repress apoptosis	20.32
Y00755	Extracellular matrix protein BM-40	Extracellular metrix	20.23
Z74616	Alpha2 (I) collagen	Extracellular metrix	12.52
D32039	Proteoglycan PG-M (V3)	Extracellular metrix	11.90
J03607	40-kDa keratin intermediate filament precursor	Extracellular metrix	11.62
AF144103	Novel chemokine family member with altered	Cytokine	9.93
	expression in human head and neck squamous cell carcinoma
AF141201	Ubiquitin fusion-degradation 1 protein (UFD1)	Protease	8.29
X02761	Fibronectin (FN)	Extracellular metrix	8.01
U06863	Follistatin-related protein precursor	Nucleoprotein	6.92
M14219	Chondroitin/dermatan sulfate proteoglycan (PG40) core protein	Extracellular metrix	6.65
M17783	Glia-derived nexin (GDN)	Protease inhibitor	6.49
U59877	Low-Mr GTP-binding protein (RAB31)	Signal transduction	5.97
AF000989	Thymosin beta 4 Y isoform (TB4Y)	Thymosin isoform	5.71
L20688	GDP-dissociation inhibitor protein (Ly-GDI)	Signal transduction	5.62
X57351	1-8D gene from interferon-inducible gene	Signal transduction	5.51
U18728	Lumican	Extracellular metrix	5.15
L02326	Lambda-like gene	Immunity correlation	4.77
M14144	Vimentin	Extracellular metrix	4.64
J05633	Integrin beta-5 subunit	Cell adhesion molecule	4.42
AF070523	JWA protein	-	4.32
M27749	Immunoglobulin-related 14.1 protein	Immunity correlation	4.28
S83308	Sry-related HMG box gene (SOX5)	Transcription factor	4.16
U05875	Interferon gamma receptor accessory factor-1 (AF-1)	Immunity correlation	3.92
M17733	Thymosin beta-4	Thymosin isoform	3.89
M20259	Thymosin beta-10	Thymosin isoform	3.75
M36501	Alpha-2-macroglobulin	Protease inhibitor	3.72
AF026977	Microsomal glutathione S-transferase 3 (MGST3)	Oxidation-reduction	3.62
M14630	Prothymosin-α	Nucleoprotein	3.45

Table 2 Under-expressed genes in pancreatic carcinoma

Accession number	Gene name	Gene function	Ratio value
U96628	Nuclear antigen H731-like protein	Tumor suppressor	0.16
U72649	B-cell translocation gene 2 (BTG2)	Tumor suppressor	0.18
Y15409	Putative glucose 6-phosphate translocase	Gluconeogenesis	0.18
Z21507	Elongation factor-1-delta	Translation factor	0.20
L13463	Helix-loop-helix basic phosphoprotein (G0S8)	Cell cycle correlation	0.21
S68805	L-arginine:glycine amidinotransferase	Amino transferase	0.22
AF041474	BAF53a (BAF53a)	Chromatin reformation	0.22
X05130	Prolyl 4-hydoxylase beta subunit	Hydroxylase	0.22
AF067855	Geminin	Cell cycle correlation	0.25
D87810	Phosphomannomutase	Glycometabolism	0.25
D28540	CDC10 homologue	Cell cycle correlation	0.27
L37368	RNA-binding protein	RNA metabolism	0.27
Y00711	Lactate dehydrogenase B (LDH-B)	Dehydrogenase	0.27
M24103	Trans-golgi network glycoprotein 51 (TGN)	-	0.29
M64930	Protein phosphatase 2A beta subunit	Signal transduction	0.29
X81197	Archain	Membranin	0.31
U75686	Polyadenylate binding protein	Signal transduction	0.32
AF133659	ATP-binding cassette 7 iron transporter (ABC7)	Iron transfer	0.32
M61832	S-adenosylhomocysteine hydrolase (AHCY)	Hydrolase	0.33
Z23064	HnRNP G protein	RNA-binding protein	0.34
X85960	TRK-T3 oncogene	Oncogene	0.35
L18887	Calnexin	Calcium binding protein	0.35
J02966	Mitochondrial ADP/ADT translocator	ATP/ADP transport	0.35
X78678	Ketohexokinase	Glycometabolism	0.35
M58460	75-kD autoantigen (PM-Sc1)	Autoantigen	0.35
L12711	Transketolase (tk)	Ribose metabolism	0.35
S75311	Glycosyl phosphatidylinositol (GPI)-linked glycoprotein CD24	Signal transduction	0.35
U46838	MCM105 protein	Cell cycle correlation	0.36
Y11312	Phosphoinositide 3-kinase	Signal transduction	0.36
U83908	PDCD4 (programmed cell death 4)	Tumor suppressor	0.36