Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice

Table 1 Effect of prokinetic agents on gastric emptying and small intestinal transit in mice

Treatment1 (mg/kg)	GE (%)	SIT (%)
Control	41.15 ± 3.76	51.11 ± 1.59
Cisapride (10) p.o.	92.98 ± 1.76a	61.46 ± 3.01
Metoclopramide (20) p.o.	83.14 ± 5.59a	76.63 ± 2.13a
Domperidone (20) p.o.	48.15 ± 2.31	58.94 ± 1.25
Erythromycin (6) p.o.	39.08 ± 5.10	52.91 ± 1.50
Mosapride (20) p.o.	77.88 ± 0.54a	57.53 ± 1.19

Each value represents mean ± sem, n = 10 in control group and n = 5 in prokinetic drug treated group.

^*prokinetic agents were given 45 minutes prior to test meal.

^aP < 0.001 vs the control group.

Table 2 Effect of prokinetic agents on morphine induced de-lay in gastric emptying and small intestinal transit in mice

Treatment1 (mg/kg)	GE (%)	SIT (%)
Control	41.15 ± 3.76	51.11 ± 1.59
Morphine(1) s.c.	23.30 ± 2.83a	19.73 ± 1.25b
Morphine (1) s.c. +
Cisapride (10) p.o.	32.34 ± 2.52	46.28 ± 2.00d
Metoclopramide (20) p.o	42.77 ± 2.04c	34.01 ± 1.75d
Domperidone (20) p.o	32.16 ± 3.48	28.63 ± 2.47
Erythromycin (6) p.o	29.39 ± 2.53	31.19 ± 1.08
Mosapride (20) p.o	38.59 ± 1.98c	38.01 ± 1.61d

Each value represents mean ± sem, n = 5 in treatment group and n = 10 in control and morphine treated group.

^* prokinetic agents were given 45 minutes and morphine 15 minutes prior to the test meal.

^aP < 0.05 and

^bP < 0.001 vs control group.

^cP < 0.05 and

^dP < 0.001 vs morphine treated group.