PTEN encoding product: A marker for tumorigenesis and progression of gastric carcinoma

Table 1 PTEN expression in normal mucosa, intestinal metaplasia, dysplasia and carcinoma of the stomach

	n	PTEN expression		%
		+~++++	-
“Normal” mucosa	102	102	0	100.0
Intestinal metaplasia	66	65	1	98.5
Dysplasia	6	4	2	66.7a
Carcinoma	184	88	96	47.8b

^aCompared with “normal” mucosa or intestinal metaplasia, P < 0.01 (modified χ² = 18.729, 7.115);

^bCompared with “normal mucosa or intestinal metaplasia, P < 0.01 (χ² = 80.106, 52.499)

Table 2 Relationship between expression of PTEN and the biological behaviors of gastric carcinoma

	n	PTEN expression		%
		+~++++	-
Clinicopathological staging
Early	37	25	12	67.6
Advanced	147	63	84	42.9a
Lymph node metastasis
+	124	50	74	40.3b
-	60	38	22	63.3
Lauren’s classification
Intestinal type	64	37	27	57.8
Diffused type	118	49	96	41.5c
Mixed type	2	2	0	100.0
WHO’s histological classification
Papillary adenocarcinoama	20	10	10	50.0
Well-differentiaed adenocarcinoma	9	5	4	55.6
Moderated-differentiated adenocarcinoma	25	16	9	64.0
Poorly-differentiated adenocarcinoma	85	39	64	45.9
Undifferentiated adenocarcinoma	5	3	2	60.0
Signet ring-cell carcinoma(SRC)	28	7	21	25.0d
Mucinous adenocarcinoma	10	6	4	60.0
Carcinoid	1	1	0	-
Squamous cell carcinoma	1	1	0	-

^aCompared with early gastric carcinoma, P < 0.01 (χ² = 26.504);

^bCompared with non-lymph node metastasis, P < 0.01 (χ² = 8.580);

^cCompared with intestinal-type gastric carcinoma, P < 0.05 (χ² = 4.416);

^dCompared with well and moderately differentiated gastric carcinoma, P < 0.01 (χ² = 8.380)