Changes in serum and histology of patients with chronic hepatitis B after interferon alpha-2b treatment

Table 1 Changes of serum HBV DNA of patients with chronic hepatitis B (Logarithm of the value expressed by copy/ml) (^-χ±s)

	Responders (n = 9)	non-responders (n = 15)	all patients (n = 24)
pretreatment	8.52 ± 0.39	8.00 ± 0.64	8.20 ± 0.60
post-treatment	7.24 ± 0.83	7.16 ± 0.14	7.21 ± 1.14
P value	P = 0.028	P = 0.051	P = 0.002

Table 2 Changes of HAI of patients with chronic hepatitis B (^-χ±s)

	responders (n = 9)		nonresponders (n = 15)		all patients (n = 24)
	pretreatment	post-treatment	pretreatment	post-treatment	pretreatment	post-treatment
necrosis	2.57 ± 1.51	2.14 ± 1.21	2.82 ± 0.98	1.91 ± 1.04	2.72 ± 1.18a	2.06 ± 1.11
lob. inf.	3.29 ± 0.49a	1.57 ± 0.98	2.67 ± 0.82	2.36 ± 0.92	2.72 ± 0.89a	1.78 ± 1.00
portal inf.	3.00 ± 1.00	2.29 ± 1.25	2.32 ± 0.96	2.09 ± 0.94	2.58 ± 1.00	2.39 ± 0.98
necrosis	1.71 ± 1.25	1.57 ± 1.13	1.91 ± 1.14	1.36 ± 1.12	1.82 ± 1.15	1.44 ± 1.10
HAI	10.57 ± 3.6a	7.57 ± 4.12	9.41 ± 3.04	7.45 ± 3.11	9.86 ± 3.22a	7.78 ± 3.30

^aP < 0.05