Gastric Cancer
Copyright ©The Author(s) 2002.
World J Gastroenterol. Dec 15, 2002; 8(6): 987-993
Published online Dec 15, 2002. doi: 10.3748/wjg.v8.i6.987
Table 1 Abnormal expression of E-cadherinin and β-catenin in gastric carcinoma and precancerous condition
Total nE-cadherin n(%)β-catenin n(%)
Gastric carcinoma16375 (46.0)73 (44.8)
Dysplasia4416 (36.4)7 (15.9)
Intestinal metaplasia2500
Atrophic gastritis2800
Health controls1200
Table 2 Expression of E-cadherin or β-catenin and Gross Ap-pearance
NoE-cadherin expression (%)
β-catenin expression (%)
AbnormalP valueAbnormalP value
Tumor size (cm)163
0-4.94816 (33.3)14 (28.2)
5.0-9.97630 (35.5)16.5829 (36.2)21.41
≥ 10.03929 (74.4)< 0.005a30 (78.9)< 0.005a
Gross appearance139
BorrmannI121 (8.3)2 (16.7)
BorrmannII163 (18.8)3 (18.8)
BorrmannIII8035 (43.8)11.9232 (40.0)9.65
BorrmannIV3121 (67.7)< 0.005b24 (77.4)< 0.005b
Table 3 Relationship Between Expression of E-cadherin or β-catenin and Histopathological Features in Gastric Carcinoma
NoE-cadherin expression (%)
β-catenin expression (%)
AbnormalP valueAbnormalP value
pT category
T1/T26528 (43.1)29 (44.6)
T3/T49847 (48.0)NS44 (44.9)NS
pN category
N-negative7129 (40.8)20 (28.2)14.56
N-positive9246 (50.0)NS53 (57.6)< 0.005
WHO classification
Adenocarcinoma160
Papillary163 (18.8)a2 (7.1)a
Tubular10948 (44.0)46 (42.2)
Mucinous2413 (54.2)8.4715 (62.5)7.05
Signet ring118 (72.7)< 0.0057 (63.3)< 0.01
Undiff. carcinoma33 (100)3 (100)
Lauren classification
Intestinal type10836 (33.3)b18.1834 (31.5)b17.79
Diffuse type4029 (72.5)< 0.00528 (70.0)< 0.005
Mixed type1510 (66.7)11 (73.3)