Expression of MMP-2, TIMP-2 protein and the ratio of MMP-2/TIMP-2 in gallbladder carcinoma and their significance

Table 1 Expression of MMP-2, TIMP-2 and ratio of MMP-2/TIMP-2 in carcinoma and polypoid lesions of gallbladder (^-x±s)

	n	MMP-2	TIMP-2	MMP-2/TIMP-2
PLG	15	1.030 ± 0.054	1.104 ± 0.072	0.937 ± 0.078
GBC	45	1.123 ± 0.108a	1.077 ± 0.090	1.050 ± 0.013b

PLG: polypoid lesions of the gallbladder; GBC: gallbladder carcinoma.

^aP = 0.002,

^bP = 0.003.

Table 2 Expression and correlation of MMP-2 and TIMP-2 proteins and ratio of MMP-2/TIMP-2 and clinical-patho-logical parameters of patients with carcinoma of the gall-bladder (^-x±s)

	n	MMP-2	TIMP-2	MMP-2/TIMP-2
histological type
adenocarcinoma	30	1.140 ± 0.113	1.077 ± 0.089	1.064 ± 0.143
papillary carcinoma	6	1.101 ± 0.106	1.117 ± 0.094	0.990 ± 0.106
others	9	1.082 ± 0.086	1.042 ± 0.084	1.043 ± 0.101
differentiated degree
well	24	1.117 ± 0.099	1.089 ± 0.095	1.031 ± 0.114
moderate	11	1.041 ± 0.131	1.062 ± 0.083	1.081 ± 0.159
poor	10	1.120 ± 0.110	1.064 ± 0.086	1.059 ± 0.144
Nevin stage
S1,S2	11	1.063 ± 0.077	1.168 ± 0.067	0.914 ± 0.086
S3-S5	34	1.143 ± 0.110a	1.048 ± 0.075b	1.094 ± 0.112c
Infiltration level
muscular	13	1.088 ± 0.099	1.170 ± 0.062	0.932 ± 0.093
serosal	32	1.137 ± 0.109	1.039 ± 0.069b	1.097 ± 0.114c
Lymph node
LN (+)	29	1.131 ± 0.109	1.039 ± 0.076	1.092 ± 0.12
LN (-)	16	1.120 ± 1.107	1.147 ± 0.083b	0.973 ± 0.114c
Liver invasion
(+)	21	1.136 ± 0.107	1.048 ± 0.074	1.087 ± 0.107
(-)	24	1.112 ± 0.110	1.103 ± 0.095b	1.017 ± 0.143

^aP < 0.05,

^bP < 0.05, ^CP < 0.05.