ROC curves in evaluation of serum fibrosis indices for hepatic fibrosis

Table 1 ROC curves of five serum fibrosis indexes

Indices	AUC	P Vaule	cut-off point	Sensitivity	Specificity	r Vaule
PIIINP	0.800	0.000	≥ 5.61 μg/L	82.7%	62.5%	0.452
HA	0.728	0.003	≥ 145.2 ng/mL	62.2%	87.5%	0.497
PCIII	0.727	0.004	≥ 137.4 μg/L	59.2%	81.2%	0.404
C- IV	0.583	0.287	≥ 74.2 μg/L	55.1%	68.7%	0.238
LN	0.463	0.636	≥ 156.65 ng/mL	37.8%	75.0%	0.128

Right diagnosis index (r) = sensitivity + specificity -1

Table 2 Parameter of combination diagnosis with several fi-brosis indexes

Combination	Sensitivity (%)	Specificity (%)
HA + PIIINP	55.1	87.5
HA + PCIII	50.0	87.5
HA + LN	27.6	100
HA + C-DIV	42.9	100
HA + LN + C-IV	21.4	100
HA + LN + PIIINP	24.5	100
HA + LN + PCIII	24.5	100
HA + C-IV + PIIINP	38.8	100
HA + C-IV + PCIII	38.8	100
HA + LN + C-IV + PIIINP	19.4	100
HA + LN + C-IV + PCIII	19.4	100

Table 3 The relationship between hepatic fibrosis indexes and inflammation grades

G	n	PIIINP(μg/L)	HA(ng/mL)	PCIII(μg/L)	C-IV(μg/L)	LN(ng/mL)
1	45	8.32 ± 5.09	144.78 ± 123.31	138.23 ± 77.63	73.89 ± 23.61	155.43 ± 55.48
2	36	13.16 ± 8.07b	211.26 ± 187.17	164.22 ± 65.69b	6.26 ± 52.56	138.76 ± 43.42
3	27	15.61 ± 7.05b	476.26 ± 296.44b	190.06 ± 75.10b	109.75 ± 42.12b	161.52 ± 34.25
4	6	15.60 ± 5.41b	562.08 ± 274.47b	261.68 ± 127.77b	123.10 ± 41.60b	154.60 ± 20.03

^bP < 0.01; Compare to G1

Table 4 Correlation between serum fibrosis indexes and his-tology classification

	PIIINP	HA	PCIII	C-IV	LN
Inflammation grads	0.463b	0.523b	0.446b	0.363b	0.234
Fibrosis stages	0.403b	0.553b	0.412b	0.351b	0.194

^bP < 0.01