Efficacy of intraperitoneal thermochemotherapy and immunotherapy in intraperitoneal recurrence after gastrointestinal cancer resection

Table 1 The clinicopathological stages and surgical procedures in each group

Groups	n	Male	Female	Age(yrs)	Stages(n)	Radical	Non-radical
Group I	65	39	26	62.5 ± 6.6	-	57	8
Gastric cancer	19	12	7	61.7 ± 5.5	T3II(9)T4IIIA(7)T4III B(3)	16	3
Colorectal cancer	46	27	19	64.4 ± 3.9	B(20)C1(12)C2(9)D(5)	41	5
Group II	73	48	25	65.4 ± 8.7	-	62	11
Gastric cancer	23	16	7	67.1 ± 7.6	T3II(11)T4IIIA(8)T4IIIB(4)	19	4
Colorectal cancer	50	32	18	63.3 ± 5.2	B(22)C1(13)C2(8)D(7)	43	7

Control group: (1) Gastric cancer: papilloadenocarcinoma, 7 cases; tuboadenocarcinoma, 6 cases; lowly-differentiated adenocarcinoma, 2 cases; mucoadenocarcinoma, 1 case; signet ring cell carcinoma, 2 cases; and undifferentiated carcinoma 1 case; (2)Colorectal cancer: highly and intermediately differentiated adenocarcinoma, 29 cases; mucoadenocarcinoma, 12 cases; and undifferentiated carcinoma 5 cases. Therapy group: (1) Gastric cancer: papilloadenocarcinoma, 9 cases; tuboadenocarcinoma, 6 cases; lowly-differentiated adenocarcinoma, 2 cases; mucoadenocarcinoma, 2 cases; signet ring cell carcinoma, 2 cases; and undif-ferentiated carcinoma 2 cases; Colorectal cancer: highly and intermediately differentiated adenocarcinoma, 33 cases; mucoadenocarcinoma, 12 cases; and undifferentiated carcinoma 5 cases.

Table 2 The levels of some Th1 cytokines in peripheral blood of patients before and after immunotherapy (pg/mL)

Groups n	The level of the cytokines						P
	IL-2		TNF-β		IFN-γ
	Pre-therapy	Post-therapy	Pre-therapy	Post-therapy	Pre-therapy	Post-therapy
group I (65)	10.2 ± 3.7	9.5 ± 3.8	25.3 ± 7.4	24.9 ± 4.5	29.5 ± 6.9	27.7 ± 7.3	>0.25
group II (73)	13.5 ± 6.7	38.4 ± 6.2	18.0 ± 4.6	55.4 ± 10.1	27.4 ± 7.1	77.1 ± 18.2	< 0.01

Table 3 The therapeutic efficiency of intraperitoneal thermochemotherapy combined with IL-2 immunotherapy

Groups	n	Intraperitoneal recurrent rate (%)	Hepatic metastasis rate(%)	3-year survival rate(%)
Group I	65	29.2(19/65)	16.9(11/65)	47.7(31/65)
Group II	73	12.3(9/73)b	10.9(8/73)a	65.8(48/73)a

^aP < 0.05 vs control group,

^bP < 0.01 vs control group