Estrogen reduces CCL4- induced liver fibrosis in rats

Table 1 Liver enzymes, serum fibrosis indicators and hepatic antioxidation (¯x ± s)

Group	n	ALT (nkat/L)	AST (nkat/L)	HA (μg/L)	CIV (μg/L)	MDA (nmol/g)	SOD (kNU/g)
Males
Control	10	31 ± 6	66 ± 18	115 ± 31	18 ± 5	3.1 ± 0.9	8.0 ± 1.6
CCL4	10	576 ± 262a	699 ± 241a	530 ± 122a	54 ± 14a	10.5 ± 3.4a	2.2 ± 1.1a
CCL4 + E	8	355 ± 125c	314 ± 179c	232 ± 78c	30 ± 10c	6.6 ± 2.8c	5.0 ± 1.6c
CCL4 + Tam	8	884 ± 294c	1073 ± 453c	703 ± 187c	69 ± 5c
Females
Control	10	35.8 ± 7.9	64.5 ± 20.8	121 ± 26	17 ± 4	3.0 ± 0.8	8.7 ± 2.8
CCL4	9	540 ± 252a	631 ± 268a	388 ± 81a	41 ± 11a	7.1 ± 2.1a	4.0 ± 1.5a
CCL4 + Ovx	10	658 ± 220	697 ± 240	586 ± 145c	53 ± 14c	9.1 ± 2.9c	2.8 ± 1.0c
CCL4 + E	8	314 ± 163c	302 ± 153c	267 ± 83c	29 ± 7c	4.7 ± 2.2c	5.9 ± 2.0c
CCL4 + Ovx + E	9	311 ± 146c	321 ± 121c	236 ± 119c	31 ± 7c	4.8 ± 2.3c	6.2 ± 2.5c

^aP < 0.05, vs control;

^cP < 0.05, vs CCL₄