Effects of the tyrosine protein kinase inhibitor genistein on the proliferation, activation of cultured rat hepatic stellate cells

Table 1 Flow cytometric analysis of α-SMA, c-fos, c-jun and cyclin D₁ expression in HSCs (the specific fluorescence intensity)

Groups	HSC control for 24 h	10-7 mol/Lgenistein treated for 24 hrs	t test	HSC control for 48 hrs	10-7 mol/Lgenistein treated for 48 hrs	t test
α-SMA Detected	6.15 ± 4.03	5.01 ± 3.30	t = 15.39	12.8 ± 10.4	9.54 ± 6.39	t = 15.03
cell numbers (n)	4857	5086	P < 0.05	2940	3985	P < 0.05
c-fos Detected	19.4 ± 7.55	16.3 ± 5.74	t = 20.64	14.7 ± 5.68	12.1 ± 4.18	t = 18.68
cell numbers (n)	3122	7649	P < 0.05	2412	2917	P < 0.05
c-jun Detected	17.22 ± 5.49	15.69 ± 4.77	t = 13.32	7.99 ± 4.11	6.74 ± 2.05	t = 3.20
cell numbers (n)	3454	5100	P < 0.05	6589	4194	P < 0.05
Cyclin D1 Detected	25.6 ± 11.1	24.0 ± 9.98	t = 10.23	5.76 ± 2.05	3.00 ± 1.05	t = 66.32
cell numbers (n)	8604	9569	P < 0.05	5615	5584	P < 0.05