Hepatoprotective role of ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice

doi:10.3748/wjg.v8.i4.728

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Aug 15, 2002 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 15, 2002; 8(4): 728-733
Published online Aug 15, 2002. doi: 10.3748/wjg.v8.i4.728

Table 1 Effect of Ganoderma lucidum polysaccharide (GLP) on the weight of liver and the activity of serum alanine transaminase (ALT) in BCG-induced immune hepatic injury in mice (¯x ± s)

Group	Liver weight (g)	ALT (U·L^-1)
Control	0.99 ± 0.16	22.03 ± 10.99
BCG (125 mg·kg^-1)	1.79 ± 0.24^b	245.18 ± 41.03^b
BCG (125 mg·kg^-1) + LPS (125 μg·kg^-1)	1.84 ± 0.14^b	285.88 ± 23.81^b^c
BCG (125 mg·kg^-1) + GLP (25 mg·kg^-1)	1.78 ± 0.20^b	236.86 ± 27.94^b
BCG (125 mg·kg^-1) + GLP (50 mg·kg^-1)	1.57 ± 0.18^b^c	189.81 ± 43.99^b^c
BCG (125 mg·kg^-1) + GLP (100 mg·kg^-1)	1.28 ± 0.20^b^d	178.78 ± 13.16^b^d
BCG (125 mg·kg^-1) + GLP (200 mg·kg^-1)	1.41 ± 0.43^b^c	208.18 ± 27.93^b^c

^aP < 0.05,

^bP < 0.01 compared with control.

^cP < 0.05,

^dP < 0.01 compared with BCG-pretreated group. n = 9 mice (liver weight groups) or 10 mice (ALT groups).

Table 2 Effect of Ganoderma lucidum polysaccharide (GLP) on the granuloma formation (numbers/microscopic view) in BCG -pretrested mice hepatic histological slides. (¯x ± s)

Croup	Granulomas
Control	0
BCG (125 mg·kg^-1)	64.67 ± 4.97^b
BCG (125 mg·kg^-1) + LPS (125 μg·kg^-1)	54.40 ± 4.93^b
BCG (125 mg·kg^-1) + GLP (50 mg·kg^-1)	60.00 ± 4.24^b
BCG (125 mg·kg^-1) + GLP (100 mg·kg^-1)	4.00 ± 1.22^b^d
BCG (125 mg·kg^-1) + GLP (200 mg·kg^-1)	36.80 ± 5.81^b^d

^aP < 0.05,

^bP < 0.01 compared with control. ^cP < 0.05,

^dP < 0.01 compared with BCG-pretreated group. n = 5 microscopic views.

Table 3 Effects of Ganoderma lucidum polysaccharide (GLP) on the alanine transaminase (ALT) activity and nitrite (NO₂^-) production induced by BCG-prestimulating in the presence or absence of cytokines mixture (CM) in primary cultured mice hepatocytes in vitro (¯x ± s)

Group	ALT (U·L^-1)	NO₂^- (μmol·L^-1)
Control	11.52 ± 1.41^b	1.41 ± 0.72^a
BCG	17.87 ± 3.41	3.52 ± 1.72
BCG + GLP (50 mg·k^-1)	21.30 ± 2.87	3.95 ± 1.27
BCG + GLP (200 mg·k^-1)	18.03 ± 2.24	3.24 ± 1.08
BCG + Cytokines Mixture (CM)	46.34 ± 4.17^b	13.53 ± 5.58^b
BCG + CM + GLP (50 mg·k^-1)	23.98 ± 6.33^a^d	4.11 ± 2.26^d
BCG + CM + GLP (200 mg·k^-1)	20.61 ± 3.74^d	3.49 ± 1.38^d

^aP < 0.05,

^bP < 0.01 compared with BCG-pretreated group; ^cP < 0.05,

^dP < 0.01 compared with BCG + CM group. n = 7 mice. (3 wells for each treatment in each experiment).

Citation: Zhang GL, Wang YH, Ni W, Teng HL, Lin ZB. Hepatoprotective role of ganoderma lucidum polysaccharide against BCG-induced immune liver injury in mice. World J Gastroenterol 2002; 8(4): 728-733
URL: https://www.wjgnet.com/1007-9327/full/v8/i4/728.htm
DOI: https://dx.doi.org/10.3748/wjg.v8.i4.728