Anti-inflammatory effect of cholecystokinin and its signal transduction mechanism in endotoxic shock rat

Table 1 Inhibitory effect of CCK-8 on LPS stimulated nitrite production in serum, lung and spleen (n = 6)

Group	2 h	6 h	12 h
Serum (μmol•L-1)
Control	36.8 ± 2.2	39.2 ± 3.2	33.8 ± 4.1
LPS	78.2 ± 7.4b	250.9 ± 19.6b	302.9 ± 41.2b
CCK-8 + LPS	48.5 ± 5.3d	124.8 ± 4.9bd
CCK-8	37.3 ± 2.3	32.4 ± 6.6
Lung (μmol•g-1)
Control	48.9 ± 7.6	47.2 ± 4.7	51.2 ± 6.1
LPS	117.5 ± 6.7b	140.6 ± 24.1b	186.6 ± 8.3b
CCK-8 + LPS	81.9 ± 10.8bd	114.8 ± 8.3bd
CCK-8	52.6 ± 5.6	44.0 ± 2.3
Spleen (μmol•g-1)
Control	53.9 ± 5.6	48.5 ± 9.0	49.8 ± 6.1
LPS	71.3 ± 8.9b	74.7 ± 4.2a	63.5 ± 3.8a
CCK-8 + LPS	59.6 ± 3.3c	46.5 ± 11.0d
CCK-8	45.0 ± 2.9	42.7 ± 2.3

^aP < 0.05,

^bP < 0.01 vs Control,

^cP < 0.05,

^dP < 0.01 vs LPS