Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B

doi:10.3748/wjg.v8.i4.679

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Aug 15, 2002 (publication date) through Apr 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Aug 15, 2002; 8(4): 679-685
Published online Aug 15, 2002. doi: 10.3748/wjg.v8.i4.679

Table 1 Ultrasound image scoring for liver fibrosis

Items	1	2	3
Liver surface	Normal (smooth)	Irregular	Waved-shaped (or serrated)
Liver edge	Normal (sharp)	Blunt at tip	Blunt at the edge
Liver parenchyma	Normal (even)	Rough	Nodular (or patch-like)
Intra-hepatic vessels	Normal (clear)	Elusive	Unevenly narrow, wide, thick or thin

Table 2 Correlation between serum fibrotic markers and fibrotic stages

Stages (n)	HA (μg/L)	LM (μg/L)	IV-C (μg/L)	PIIIP (μg/L)
S0 (4)	103 ± 67.6	116 ± 34.8	232 ± 148	6.7 ± 2.3
S1 (14)	156 ± 175	103 ± 30	129 ± 92^a^c	7.4 ± 3.1^a^c
S2 (31)	197 ± 175	99 ± 26.5	178 ± 138	8.5 ± 4.1^a
S3 (35)	252 ± 243	107 ± 22	227 ± 123	10.8 ± 4.9
S4 (36)	239 ± 176	108 ± 22.6	232 ± 158	13 ± 7.8

^aP < 0.05, vs S4;

^cP < 0.05, S3.

Table 3 Correlation between serum fibrotic markers and inflammatory grades

Grades (n)	HA (μg/L)	LM (μg/L)	IV-C (μg/L)	PIIIP (μg/L)
G0 (1)	96	106	212	9.2
G1 (14)	136 ± 161^a^c	119 ± 26	146 ± 92^a	6.38 ± 2.4^a^c
G2 (35)	165 ± 158^a	96 ± 22	178 ± 128^a	7.71 ± 3.7^a^c
G3 (49)	258 ± 216	105 ± 25	211 ± 129	12 ± 5.85
G4 (21)	276 ± 202	107 ± 24	276 ± 178	14 ± 7.44

^aP < 0.05, vs S4;

^cP < 0.05, S3.

Table 4 Serum HA, LM, IV-C and PIIIP contents before, during and after treatment

		HA (μg/L)	LM (μg/L)	IV-C (μg/L)	PIIIP (μg/L)
IFN-γ group	Before	250 ± 210	94 ± 27	112 ± 64	10.4 ± 5.0
	During	225 ± 248	110 ± 22	219 ± 143	10.2 ± 4.4
	After	185 ± 172	104 ± 26	212 ± 105	8.0 ± 2.8
SA-B group	Before	267 ± 211	103 ± 17	294 ± 155	13.2 ± 8.1
	During	219 ± 243	117 ± 21	248 ± 164	11.9 ± 4.9
	After	169 ± 183^a	118 ± 24	190 ± 142^b^c	9.7 ± 5.3

^aP < 0.05,

^bP < 0.01, vs before treatment;

^cP < 0.05, vs during treatment.

Table 5 Abnormal rates of serum fibrotic markers before and after treatment (abnormal rate (%) = number of abnormal cases/total cases)

Groups		HA > 110 μg/L	LN > 132 μg/L	IV-C > 140 μg/L	PIIIP ≥ 5 μg/L
IFN-γ	Before	21/30 (70%)	1/30 (3.33%)	6/30 (20.0%)	20/29 (68.97%)
	After	17/30 (56.7%)	3/30 (10.0%)	20/30 (66.7%)	25/29 (86.2%)
SA-B	Before	24/30 (80%)	1/30 (3.33%)	24/30 (80.0%)	26/28 (92.86%)
	After	11/30 (36.67%)^a	7/30 (23.23%)	15/30 (50.0%)^a	25/28 (89.29%)

^aP < 0.05, vs before treatment.

Table 6 Decrease of 4 serum fibrotic markers > 30% after treatment in two groups

Groups	Total number 3	Decrease of markers > 30%	Decrease of 2 markers > 30%	Decrease of 1 marker > 30%
IFN-γ	30	1 (3.33%)	6 (20%)	13 (43.33%)
SA-B	30	9 (30%)	7 (23.33%)	7 (23.33%)

P < 0.05, vs IFN-γ

Table 7 Change of ALT activities before and after treatment n (%)

Group	Recovered	Decreased (> 50%)	Decreased (< 50%)	Stable	Increased
IFN-γ	6 (20)	4 (13.33)	4 (13.33)	2 (6.67)	14 (46.67)
SA-B	6 (20)	5 (16.67)	8 (26.67)	4 (13.33)	7 (23.33)^a

^aP < 0.05, vs IFN-γ.

Table 8 Change of AST activities before and after treatment n (%)

Group	Recovered	Decreased (> 50%)	Decreased (< 50%)	Stable	Increased
IFN-γ	8 (26.67)	3 (10.0)	4 (13.33)	4 (13.33)	11 (36.67)
SA-B	7 (23.33)	2 (6.67)	4 (13.33)	5 (16.67)	12 (40.00)

Table 9 Change of ultrasound image scoring

Group	n	Before treatment	After treatment	Improved n (%)	Deteriorated n (%)
IFN-γ	29	5.38 ± 1.52	5.75 ± 1.45	4 (13.79)	11 (37.93)
SA-B	30	5.10 ± 1.52	4.70 ± 1.44	9 (30)	2 (6.67)^a

Comparison of χ² test between two groups,

^aP < 0.05

Table 10 Correlation between change of fibrotic stages before and after treatment, liver function and serum fibrotic markers before treatment in SA-B group

Items	*Improved (n =* 11)**	Unchanged (n = 13)	Deteriorated (n = 6)
Albumin (g/L)	40 ± 4.4	39.3 ± 6.5	39.5 ± 3.0
Globulin (g/L)	31.1 ± 6.7	33.9 ± 6.9	30.9 ± 8.5
ALT (U)	64 ± 41^a	108 ± 83	201 ± 155
AST (U)	48 ± 29^b	73 ± 55^a	155 ± 108
GGT (U)	72 ± 44	99 ± 47	96 ± 54
Total bilirubin (mmol)	14.9 ± 3.9^b	15.0 ± 6.6^a	21 ± 10
Direct bilirubin (mmol)	2.9 ± 1.7	3.1 ± 2.3	5.0 ± 4.0
HA (μg/L)	172 ± 110	292 ± 188	386 ± 330
LN (μg/L)	106 ± 10	107 ± 21	91 ± 18
IV-C (μg/L)	248 ± 88	352 ± 176	284 ± 164
PIIIP (μg/L)	10.2 ± 6.8	14.8 ± 7.3	15 ± 10.2

Compared with elevation of stages,

^aP < 0.05,

^bP < 0.01

Table 11 Correlation between change of fibrotic stages before and after treatment, liver function and serum fibrotic markers before treatment in IFN-γ group

Items	Improved (n = 9)	Unchanged (n = 12)	Deteriorated (n = 9)
Albumin (g/L)	39.9 ± 5.0	40.8 ± 4.6	40.6 ± 6.7
Globulin (g/L)	28.1 ± 4.6	30.7 ± 4.0	31.9 ± 5.3
ALT activities (U)	94 ± 56	79 ± 51	171 ± 286
AST activities (U)	77 ± 53	56 ± 33	80 ± 73
GGT activities (U)	76 ± 41	76 ± 48	81 ± 40
Total bilirubin (mmol)	13.4 ± 7.6	16.5 ± 6.4	18.9 ± 7.0
Direct bilirubin (mmol)	3.0 ± 2.2	3.6 ± 2.5	3.3 ± 2.0
HA (μg/L)	219 ± 230	284 ± 246	237 ± 145
LM (μg/L)	97 ± 34	87 ± 18	102 ± 30
IV-C (μg/L)	128 ± 84	104 ± 56	92 ± 32
PIIIP (μg/L)	12.0 ± 6.2	9.1 ± 5.5	10.9 ± 2.3

Citation: Liu P, Hu YY, Liu C, Zhu DY, Xue HM, Xu ZQ, Xu LM, Liu CH, Gu HT, Zhang ZQ. Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B. World J Gastroenterol 2002; 8(4): 679-685
URL: https://www.wjgnet.com/1007-9327/full/v8/i4/679.htm
DOI: https://dx.doi.org/10.3748/wjg.v8.i4.679