Effect of areca on contraction of colonic muscle strips in rats

Table 1 Effect of areca on the contractile frequency of colonic contractile in rats (¯x ± s, waves·min^-1, n = 12)

	Areca (g•L⁻¹)
	0	10	0	100	0	1000
LMPC	1.8 ± 0.2	1.9 ± 0.2	2.2 ± 0.2	2.5 ± 0.3	1.8 ± 0.2	1.8 ± 0.4
CMPC	1.5 ± 0.1	1.5 ± 0.1	1. 6 ± 0.1	2.1 ± 0.2a	1.6 ± 0.1	2.3 ± 0.1b
LMDC	1.3 ± 0.1	1.3 ± 0.1	1.5 ± 0.1	2.3 ± 0.2a	1.5 ± 0.2	2.7 ± 0.5b
CMDC	0.7 ± 0.1	0.7 ± 0.1	0.6 ± 0.1	0.6 ± 0.1	0.6 ± 0.1	0.6 ± 0.1

LMPC: longitudinal muscle of proximal colon; CMPC: circular muscle of proximal colon; LMDC: longitudinal muscle of distal colon; CMDC: circular muscle of distal colon.

^aP < 0.05,

^bP < 0.01 vs control (0).

Table 2 Effect of areca on the mean contractile amplitude and the resting tension of colon, and the motilityindex of distal colon after atropine pretreatment in rats (¯x ± s, n = 12)

	LMPC		CMPC		LMDC		CMDC
	T/g	A/mm	T/g	A/mm	T/g	A/mm	T/g	MI/mm·s-1
Areca	0.44 ± 0.12b	-45.8 ± 7.2b	0	40.0 ± 3.5b	0.71 ± 0.14b	79.7 ± 12.8b	0.11 ± 0.05a	86.6 ± 17.3b
Atropine	0	0.1 ± 0.1	0	0.6 ± 1.4	0	1.3 ± 3.0	0	0.9 ± 1.3
Atropine + Areca	0.17 ± 0.03bc	-30.5 ± 2.9	0	36.9 ± 2.5b	0.03 ± 0.01ab	70.9 ± 13.6b	0.03 ± 0.02	32. ± 98.3bc

T, the resting tension; A, the mean contractile amplitude; MI, the motility index.

^aP < 0.05,

^bP < 0.001 vs control.

^cP < 0.05, ^dP < 0.001 vs areca.