Mechanical properties of hepatocellular carcinoma cells

doi:10.3748/wjg.v8.i2.243

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Apr 15, 2002; 8(2): 243-246
Published online Apr 15, 2002. doi: 10.3748/wjg.v8.i2.243

Table 1 Viscoelastic properties of hepatocytes and HCC cells under the action of colchicines (¯x ± s)

[colchicine] (mg•L^-1)	Hepatocytes			HCC cells
[colchicine] (mg•L^-1)	K₁ (N•m^-2)	K₂ (N•m^-2)	μ (Pa•s)	K₁ (N•m^-2)	K₂ (N•m^-2)	μ (Pa•s)
0.0	87.5 ± 12.1	33.3 ± 10.3	5.9 ± 3.0	103.6 ± 12.6	42.5 ± 10.4	4.5 ± 1.9
1.0	95.4 ± 14.1^a	33.2 ± 7.7	3.9 ± 1.7^b	86.7 ± 10.0^b	20.6 ± 2.9^b	4.5 ± 1.5
15.0	107.1 ± 23.0^b	39.6 ± 12.2^a	5.3 ± 1.9	31.4 ± 8.0^b	7.0 ± 1.9^b	1.3 ± 0.6^b
30.0	99.5 ± 11.1^b	28.0 ± 7.3^a	4.0 ± 1.8^b	53.5 ± 12.9^b	12.3 ± 4.8^b	2.1 ± 1.0^b
60.0	104.4 ± 13.0^b	30.6 ± 6.5	3.5 ± 1.1^b	61.6 ± 16.0^b	16.5 ± 6.5^b	2.3 ± 1.2^b

^aP < 0.05,

^bP < 0.01 vs normal control

Table 2 Viscoelastic properties of hepatocytes and HCC cells under the action of vinblastine (¯x ± s)

[vinblastine] (mg•L^-1)	Hepatocytes			HCC cells
[vinblastine] (mg•L^-1)	K₁ (N•m^-2)	K₂ (N•m^-2)	μ (Pa•s)	K₁ (N•m^-2)	K₂ (N•m^-2)	μ (Pa•s)
0.0	87.5 ± 12.1	33.3 ± 10.3	5.9 ± 3.0	103.6 ± 12.6	42.5 ± 10.4	4.5 ± 1.9
0.05	115.9 ± 15.9^b	42.4 ± 8.8^b	6.1 ± 2.3	118.4 ± 19.7^b	23.1 ± 6.0^b	5.6 ± 2.3
0.25	128.7 ± 2.4^b	54.0 ± 6.3^b	9.8 ± 1.6^b	93.2 ± 11.3^b	17.0 ± 3.2^b	2.9 ± 1.0^b
0.75	138.3 ± 23.2^b	51.4 ± 13.4^b	8.2 ± 3.3^a	84.5 ± 6.2^b	15.2 ± 3.1^b	2.6 ± 0.8^b
2.00	117.0 ± 9.1^b	43.9 ± 7.7^b	6.2 ± 2.3	53.4 ± 12.0^b	8.7 ± 2.8^b	1.0 ± 0.5^b

^aP < 0.05,

^bP < 0.01 vs normal control

Table 3 Viscoelastic properties of hepatocytes and HCC cells under the action of cytochalasin D (¯x ± s)

[cytochalasin D] (mg•L^-1)	Hepatocytes			HCC cells
[cytochalasin D] (mg•L^-1)	K₁ (N·m^-2)	K₂ (N•m^-2)	μ (Pa•s)	K₁ (N•m^-2)	K₂ (N•m^-2)	μ (Pa•s)
0.00	87.5 ± 12.1	33.3 ± 10.3	5.9 ± 3.0	103.6 ± 12.6	42.5 ± 10.4	4.5 ± 1.9
0.25	37.7 ± 7.1^b	12.9 ± 3.3^b	2.0 ± 0.8^b	29.5 ± 11.4^b	6.5 ± 2.6^b	1.6 ± 0.8^b
0.50	39.5 ± 6.4^b	13.8 ± 3.4^b	2.6 ± 1.1^b	21.9 ± 5.2^b	5.4 ± 1.7^b	1.1 ± 0.5^b
2.50	42.4 ± 5.9^b	16.1 ± 3.3^b	2.9 ± 1.4^b	31.7 ± 3.8^b	7.1 ± 1.8^b	2.5 ± 1.0^b
5.00	44.9 ± 7.5^b	16.1 ± 3.0^b	2.6 ± 1.3^b	34.9 ± 9.4^b	8.0 ± 2.7^b	1.9 ± 0.7^b

^aP < 0.05,

^bP < 0.01 vs normal control

Table 4 Adhesive forces of HTC on artificial basement membrane (¯x ± s)

Concentration of collagen IV (mg•L^-1)	F_a (10^-10 N)
1	107.8 ± 65.4
2	182.6 ± 107.9^b
5	298.9 ± 144.1 d

^bP < 0.001 vs collagen IV 1 mg•L^-1; ^dP < 0.001 vs collagen IV 2 mg•L^-1

Table 5 Viscoelastic coefficients of HTC in different cycle (¯x ± s)

Viscoelastic coefficients	General	G₁ phase	S phase
K₁ (N•m^-2)	186.5 ± 35.6	215.3 ± 50.2	179.7 ± 33.0^b
K₂ (N•m^-2)	224.4 ± 114.5	181.9 ± 102.9	188.6 ± 87.1
μ (Pa•s)	3.1 ± 2.3	2.9 ± 1.3	4.7 ± 2.4^b

^bP < 0.001 vs G₁ phase.

Citation: Zhang G, Long M, Wu ZZ, Yu WQ. Mechanical properties of hepatocellular carcinoma cells. World J Gastroenterol 2002; 8(2): 243-246
URL: https://www.wjgnet.com/1007-9327/full/v8/i2/243.htm
DOI: https://dx.doi.org/10.3748/wjg.v8.i2.243