Methionine-dependence and combination chemotherapy on human gastric cancer cells in vitro

Table 1 The distribution of human primary gastric cancer cell cycle and the amount of cells (¯x ± s, n = 37)

Groups	Fractions in different phases			Amount of cells (× 109•L⁻¹)
	G0G1	S	G2M
Met+Hcy-	0.80 ± 0.18	0.17 ± 0.16	0.04 ± 0.06	1.64 ± 0.44
Met-Hcy+	0.69 ± 0.24b	0.24 ± 0.20b	0.07 ± 0.13	1.46 ± 0.42b

^bP < 0.01, vs Met⁺Hcy^- group.

Table 2 The distribution of human gastric mucosa epithelial cell cycle and the amount of cells (¯x ± s, n = 31)

Groups	Fractions in different phases			Amount of cells (× 109•L⁻¹)
	G0G1	S	G2M
Met+Hcy-	0.90 ± 0.13	0.07 ± 0.11	0.02 ± 0.02	1.70 ± 0.44
Met-Hcy+	0.90 ± 0.14	0.08 ± 0.11	0.03 ± 0.04	1.75 ± 0.45

Table 3 The influence of Met⁺Hcy^- or Met^-Hcy⁺ in combination with chemotherapeutic drugs to

Drug	Met+Hcy-	Met-Hcy+
ADM	0.3807 ± 0.3114	0.3175 ± 0.2003a
DDP	0.3878 ± 0.3050	0.3189 ± 0.1848b
5-FU	0.3657 ± 0.2597	0.3182 ± 0.2049a
MMC	0.3861 ± 0.2734	0.3105 ± 0.2103b
MTX	0.3649 ± 0.2811	0.3120 ± 0.2003b
Control	0.4834 ± 0.4337	0.3981 ± 0.3056b

gastric cancer cells (¯x ± s, A)

^aP < 0.05,

^bP < 0.01, vs Met⁺Hcy^-.