Review
Copyright ©The Author(s) 2001.
World J Gastroenterol. Aug 15, 2001; 7(4): 482-489
Published online Aug 15, 2001. doi: 10.3748/wjg.v7.i4.482
Table 1 Survival following surgery and adjuvant chemotherapy for pancreatic cancer
SeriesPeriodNumber
RegimenMedian survival (months)Actuarial survival (%)
TotalPDAC1 year3 year5 year
Splinter et al[43]1977-1984361828
1980-19841695-FU/DOX/MMC24
Livingstone et al[44]N/A285285N/A9
Bakkevold et al*[45]1984-198730235-FU/DOX/MMC2370704
31241145308
Baumel et al[46]1982-19884343Not specified12
1982-198852752712
Table 2 Survival following surgery and radiotherapy for pancreatic cancer
SeriesYearNumberEBRT (Gy)IORT (Gy)Median survival (months)Actuarial survival (%)
1 year3 year5 year
Willett et al[32]199316 (nm)40-502129
23 (pm)40-50110
Johnstone et al[53]19932645-552018
Zerbi et al[21]19944312.5-2019717
47124910
Di Carlo et al[54]19972714
2712.5-2017
Dobelbower et al[55]1997146.51500
610-209503533
1450-6714.564280
1027-5410-251870100
Farrell et al[56]1997146012-2516622215
Hishinuma et al[57]19983424 EBRT13 EBRT + IOR135919
Klinkenbijl et al*[58]199954pdc12.610
60pdc4017.120
Mehta et al[59]20005245-548 IORT327538
Lee et al[60]20002247
134981
Table 3 Adjuvant regional therapy for pancreatic cancer
SeriesYearNumberRegimenMedian survival (months)Actuarial survival (%)
1 year3 year5 year
Ishikawa et al[65]199420HAI + PVI54
Ozaki et al[66]199424IORT + HAI +/- PVI32
Link et al[67]199720CAI21
299.3
Beger et al[68]199924CAI2354 (4 year)
nd10.59.5 (4 year)
Table 4 Neoadjuvant therapy for pancreatic cancer
SeriesYearNumberRegimenResection rate
Positive resection margin (n)Median survival (months)Actuarial survival (%)
n%3 year5 year
Ishikawa et al[70]199423EBRT17/237422
Coia et al[71]199427EBRT + 5-FU + MMC13/27480/131643
Staleyet al[72]199639EBRT + 5-FU + IORT39/391007/391919 (4 year)
Spitz et al[73]199741EBRT + 5-FU41/91515/4119.2
Hoffman et al[74]199853EBRT + 5-FU + MMC24/534515.7
White et al[75]1999255-FU + EBRT + MMC + CPP5/2520
Wanebo et al[76]2000145-FU + EBRT + CPP9/1464
Snady et al[77]200068EBRT + 5-FU + STREP + CPP20/68293232
48 NR712113
Table 5 Results of combination therapy in patients who have undergone resection for pancreatic cancer
SeriesYearNumberRadiotherapy (Gy)ChemotherapyMedian survival (months)Actuarial survival (%)
1 year2 year3 year5 year
Kalser et al*[81]198521EBRT 405-FU2067422418
2211501578
GITSG[82]198730EBRT 405-FU1846
Conlon et al[83]199656EBRT 455-FU2035
Yeo et al[84]19975313.530
99EBRT 40-455-FU2144
21EBRT 50-575-FU + FA17.522
UKPACA[85]199835EBRT 405-FU1356382915
Abrams et al[86]199923EBRT5-FU + FA15.9
Paulino et al[87]199930EBRT5-FU26
8EBRT5.5
André et al[88]200010EBRT5-FU + FA + CPP17