Protective actions of salvianolic acid A on hepatocyte injured by peroxidation in vitro

Table 1 Effects of SA-A on ALT, AST and LDH activities in hepatocytes injured for 24 h (n = 6, ^-x±s)

Group	ALT (U·L-1)	AST (U·L-1)	LDH (U·L-1)
Normal	18 ± 2.8b	56 ± 3.8b	77 ± 38b
Control	103 ± 6.5	176 ± 9.1	1674 ± 128
10-4 mol·L-1 SA-A	49 ± 2.9bd	134 ± 5.0bd	1050 ± 83bd
10-5 mol/L SA-A	72 ± 3.9bd	177 ± 8.3	1551 ± 88
10-6 mol/L SA-A	91 ± 11.1a	177 ± 9.2	1602 ± 88
10-7 mol/L SA-A	96 ± 7.9	181 ± 6.7	1657 ± 81
10-8 mol/L SA-A	93 ± 11.4	181 ± 10.7	1684 ± 71
Vitamin E	86 ± 7.6b	182 ± 10.7	1509 ± 30a

^aP < 0.05;

^bP < 0.01, vs Control;

^dP < 0.01 vs Vitamin E.

Table 2 Effects of SA-A on the contents of MDA and GSH and the activities of SOD, CAT and GSH-PX in hepatocytes injured by peroxidation (n = 6, ^-x±s)

Group	MDA (μmol·L-1)	SOD (U·L-1)	CAT (U·L-1)	GSH (U·L-1)	GSH-PX (U·L-1)
Normal	5.11 ± 0.91b	30.4 ± 2.86b	12.8 ± 3.45b	1.27 ± 0.13b	16.7 ± 8.84b
Control	9.17 ± 0.80	59.0 ± 2.23	86.6 ± 13.00	0.36 ± 0.07	90.9 ± 11.00
10-3 mol/L SA-A	6.79 ± 0.81a	45.6 ± 3.26bd	17.3 ± 3.59bd	0.95 ± 0.02bd	65.2 ± 1.24a
10-4 mol/L SA-A	7.67 ± 1.11	55.2 ± 2.44	38.3 ± 11.82b	0.40 ± 0.04	81.8 ± 17.54
10-5 mol/L SA-A	8.27 ± 1.50	57.6 ± 3.27	49.9 ± 6.78b	0.38 ± 0.10	84.1 ± 19.11
Vitamin E	7.52 ± 0.69a	55.8 ± 4.03	27.6 ± 3.22b	0.49 ± 0.07a	63.64 ± 10.57a

^aP < 0.05,

^bP < 0.01, vs Control;

^dP < 0.01 vs Vitamin E.