Expression and significance of HBV genes and their antigens in human primary intrahepatic cholangiocarcinoma

Table 1 Positive results of 5 HBV antigens in cancerous tissues

Pathological diagnosis	Cases	HBxAg	pre-S1	pre-S2	HBsAg	HBcAg
Chc	12	8	5	5	0	0
HChC	8	7	3	3	2	0
Total (%)	20	15 (75)	8 (40)	8 (40)	2 (10)	0

Chc: intrahepatic cholangiocarcinoma. HChC: hepato-cholangiocarcinoma

Table 2 Positive results of 5 HBV antigens in surrounding hepatic tissues

Pathological diagnosis	Cases	HBxAg	pre-S1	pre-S2	HBsAg	HBcAg
CAH	8	8	5	5	2	5
CPH	6	5	1	1	1	0
CIR	5	3	3	3	3	1
Total (%)	19	16 (84.2)	9 (47.4)	9 (47.4)	6 (31.6)	6 (31.6)

CAH: Chronic active hepatis. CPH: Chronic persistent hepatitis. CIR: Liver cirrhosis

Table 3 Positive results of hybridization by 5 kinds of probe for HBV genes in cancerous tissues

Pathological diagnosis	Cases	HBV-DNA	X	pre-S	S	C
Chc	30	23	20	13	12	9
HChC	10	8	8	6	4	8
Total (%)	40	31 (77.5)	28 (70.0)	19 (47.5)	16 (40.0)	17 (42.5)

Table 4 Positive results of hybridization by 5 kinds of probe for HBV genes in surrounding hepatic tissues

Pathological diagnosis	Cases	HBV-DNA	X	pre-S	S	C
CAH	22	18	18	12	14	13
CPH	7	7	6	5	5	5
CIR	4	4	4	4	4	4
Total (%)	33	29 (87.9)	28 (84.8)	21 (63.6)	23 (69.7)	22 (66.7)