Changes of lipid metabolism in plasma, liver and bile during cholesterol gallstone formation in rabbit model

Table 1 The results of plasma lipids (mmol/L) and apolipoproteins (mg/L) for each group

	Control	Experimental groups
		1 wk	2 wk	3 wk	4 wk
TC	0.79 ± 0.03	4.50 ± 1.86a	7.23 ± 3.87a	16.35 ± 3.49aec	17.21 ± 4.78aec
TG	0.83 ± 0.21	1.10 ± 0.45	1.45 ± 0.51a	1.52 ± 0.41a	2.87 ± 0.81aec
PL	0.94 ± 0.29	2.37 ± 0.68a	3.10 ± 1.32a	6.24 ± 2.43aec	6.71 ± 2.80aec
HDL-C	0.70 ± 0.21	0.72 ± 0.30	0.52 ± 0.23	0.55 ± 0.21	0.58 ± 0.24
HDL2- C	0.32 ± 0.10	0.35 ± 0.11	0.25 ± 0.13	0.27 ± 0.11	0.31 ± 0.16
HDL3-C	0.31 ± 0.11	0.37 ± 0.17	0.26 ± 0.12	0.29 ± 0.17	0.28 ± 0.15
LDL-C	0.05 ± 0.02	0.90 ± 0.13a	1.88 ± 0.97ac	4.86 ± 0.98aec	5.56 ± 1.07aec
VLDL-C	0.06 ± 0.01	0.45 ± 0.18	1.22 ± 0.91ac	3.43 ± 0.87aec	3.76 ± 1.01aec
apoB100	0.15 ± 0.01	0.54 ± 0.06a	0.54 ± 0.10a	5.36 ± 0.11ac	6.45 ± 0.54aec
apoA I	20.82 ± 1.57	18.10 ± 2.23	17.87 ± 2.07	18.16 ± 0.74	15.96 ± 1.13g
apoC II	0.05 ± 0.01	0.15 ± 0.02a	0.30 ± 0.04ac	0.25 ± 0.01ac	0.69 ± 0.046aec
apoC III	0.17 ± 0.02	0.45 ± 0.06a	1.22 ± 0.05ac	1.62 ± 0.06aec	2.91 ± 0.07aecg

^aP < 0.05, vs Con;

^cP < 0.05, vs 1 wk;

^eP < 0.05, vs 2 wk;

^gP < 0.05, vs 3 wk.

Table 2 The results of hepatic and biliary cholesterol and bile acids

	Control	Experimental groups
		1 wk	2 wk	3 wk	4 wk
TCd	25.02 ± 6.21	33.63 ± 16.86a	36.23 ± 8.31a	65.75 ± 33.41ab	83.87 ± 35.10abc
TGd	158.72 ± 58.15	145.37 ± 21.34	142.27 ± 30.24	148.22 ± 38.16	151.52 ± 35.52
PLd	29.21 ± 7.04	34.65 ± 7.56	30.23 ± 10.16	29.02 ± 10.89	27.81 ± 9.53
GDCAe	275.35 ± 101.46	532.83 ± 258.71	413.73 ± 132.37	393.54 ± 108.71	348.14 ± 132.71
GCAe	97.81 ± 59.28	87.56 ± 59.52	73.26 ± 49.54	58.61 ± 9.89a	43.79 ± 38.74a
CHf	2.51 ± 1.36	3.58 ± 1.98	3.85 ± 1.41	4.32 ± 1.23a	5.02 ± 1.86a

^aP < 0.05, vs Con;

^bP < 0.05, vs 1, 2 wk;

^cP < 0.05, vs 3 wk;

^dHepatic TC, TG and PL (mg/g);

^eBile GDCA and GCA (mg/L);

^fBile cholesterol (mol/L).