Copyright: ©Author(s) 2026.
World J Gastroenterol. Nov 28, 2026; 32(44): 120965
Published online Nov 28, 2026. doi: 10.3748/wjg.120965
Published online Nov 28, 2026. doi: 10.3748/wjg.120965
Table 1 Characteristics of inflammatory bowel disease patients during periods of histologic inflammation and histologic remission in 1969-2017, n (%)/mean (interquartile range)/mean ± SD
| Item | Histologic remission | Histologic inflammation | Histologic inflammation in subtypes of IBD | ||
| CD | UC | IBD-U | |||
| Number of periods | 47462 | 102904 | 26168 | 70962 | 5774 |
| Number of patients | 27779 | 53719 | 15021 | 35678 | 3020 |
| Number of patients by number of periods | |||||
| 1 | 17224 (62.0) | 30142 (56.1) | 8930 (59.5) | 19412 (54.4) | 1800 (59.6) |
| 2 | 5927 (21.3) | 11806 (22.0) | 3436 (22.9) | 7775 (21.8) | 595 (19.7) |
| 3 | 2443 (8.8) | 5561 (10.4) | 1418 (9.4) | 3891 (10.9) | 252 (8.3) |
| ≥ 4 | 2185 (7.9) | 6210 (11.6) | 1237 (8.2) | 4600 (12.9) | 373 (12.4) |
| Age (years)1 | |||||
| mean ± SD | 45.9 ± 16.6 | 44.3 ± 17.6 | 41.3 ± 17.7 | 45.4 ± 17.4 | 45.5 ± 18.0 |
| Median (IQR) | 46.3 (33.4-58.6) | 43.7 (30.5-57.6) | 39.9 (26.9-54.8) | 44.8 (31.8-58.5) | 45.6 (31.0-59.3) |
| < 18 | 2319 (4.9) | 6011 (5.8) | 2300 (8.8) | 3345 (4.7) | 366 (6.3) |
| 18-40 | 15345 (32.3) | 38169 (37.1) | 10836 (41.4) | 25417 (35.8) | 1916 (33.2) |
| 40-60 | 19158 (40.4) | 36778 (35.7) | 8437 (32.2) | 26220 (37.0) | 2121 (36.7) |
| ≥ 60 | 10640 (22.4) | 21946 (21.3) | 4595 (17.6) | 15980 (22.5) | 1371 (23.7) |
| Calendar period1 | |||||
| 1969-1989 | 1257 (2.7) | 6379 (6.2) | 1721 (6.6) | 4074 (5.7) | 584 (10.1) |
| 1990-2001 | 7970 (16.8) | 29924 (29.1) | 7426 (28.4) | 20962 (29.5) | 1536 (26.6) |
| 2002-2009 | 15568 (32.8) | 32606 (31.7) | 8201 (31.3) | 23042 (32.5) | 1363 (23.6) |
| 2010-2017 | 22667 (47.8) | 33995 (33.0) | 8820 (33.7) | 22884 (32.3) | 2291 (39.7) |
| Educational attainment1 | |||||
| 0-9 years | 9182 (19.4) | 22003 (21.4) | 5701 (21.8) | 14995 (21.1) | 1307 (22.6) |
| 10-12 years | 20606 (43.4) | 43549 (42.3) | 11217 (42.9) | 30001 (42.3) | 2331 (40.4) |
| ≥ 13 years | 14868 (31.3) | 26509 (25.8) | 5932 (22.7) | 19280 (27.2) | 1297 (22.5) |
| Missing | 2806 (5.9) | 10843 (10.5) | 3318 (12.7) | 6686 (9.4) | 839 (14.5) |
| IBD duration (years)1 | |||||
| mean ± SD | 9.3 ± 8.6 | 6.6 ± 8.0 | 6.5 ± 8.3 | 6.5 ± 7.7 | 7.8 ± 9.5 |
| Median (IQR) | 7.4 (2.1-13.8) | 3.5 (0.0-10.7) | 3.1 (0.0-10.6) | 3.7 (0.0-10.6) | 3.6 (0.0-13.2) |
| 0 | 1969 (4.2) | 28345 (27.6) | 7495 (28.6) | 19334 (27.3) | 1516 (26.3) |
| 0-5 | 16646 (35.1) | 29172 (28.4) | 7554 (28.9) | 20007 (28.2) | 1611 (27.9) |
| > 5 | 28847 (60.8) | 45387 (44.1) | 11119 (42.5) | 31621 (44.6) | 2647 (45.8) |
| Number of health care visits2 | |||||
| 0 | 15871 (33.4) | 46294 (45.0) | 11082 (42.4) | 32667 (46.0) | 2545 (44.1) |
| 1 | 10057 (21.2) | 20178 (19.6) | 4790 (18.3) | 14269 (20.1) | 1119 (19.4) |
| 2-3 | 9999 (21.1) | 18351 (17.8) | 4738 (18.1) | 12611 (17.8) | 1002 (17.4) |
| ≥ 4 | 11535 (24.3) | 18081 (17.6) | 5558 (21.2) | 11415 (16.1) | 1108 (19.2) |
| Disease history1 | |||||
| Hypertension | 4076 (8.6) | 7128 (6.9) | 1642 (6.3) | 4906 (6.9) | 580 (10.1) |
| Diabetes | 2232 (4.7) | 4272 (4.2) | 839 (3.2) | 3092 (4.4) | 341 (5.9) |
| Obesity | 810 (1.7) | 1357 (1.3) | 405 (1.6) | 860 (1.2) | 92 (1.6) |
| Dyslipidemia | 1195 (2.5) | 1728 (1.7) | 308 (1.2) | 1303 (1.8) | 117 (2.0) |
| Chronic kidney diseases | 518 (1.1) | 925 (0.9) | 259 (1.0) | 590 (0.8) | 76 (1.3) |
| COPD | 605 (1.3) | 1510 (1.5) | 379 (1.5) | 1008 (1.4) | 123 (2.1) |
Table 2 Characteristics of inflammatory bowel disease patients during periods of clinically active and quiescent inflammatory bowel disease in 2006-2020, n (%)/mean (interquartile range)/mean ± SD
| Item | Quiescent IBD | Active IBD | Active IBD in subtypes of IBD | ||
| CD | UC | IBD-U | |||
| Number of periods | 293289 | 290860 | 108625 | 163417 | 18818 |
| Number of patients | 89114 | 85763 | 30092 | 49061 | 6610 |
| Number of patients by number of periods | |||||
| 1 | 30440 (34.2) | 28012 (32.7) | 9301 (30.9) | 16000 (32.6) | 2711 (41.0) |
| 2 | 18002 (20.2) | 17135 (20.0) | 5765 (19.2) | 10007 (20.4) | 1363 (20.6) |
| 3 | 12023 (13.5) | 11701 (13.6) | 4090 (13.6) | 6787 (13.8) | 824 (12.5) |
| ≥ 4 | 28649 (32.2) | 28915 (33.7) | 10936 (36.3) | 16267 (33.2) | 1712 (25.9) |
| Age (years)1 | |||||
| mean ± SD | 49.1 ± 18.5 | 49.4 ± 18.9 | 48.4 ± 18.9 | 50.1 ± 18.6 | 49.5 ± 20.3 |
| Median (IQR) | 49.2 (34.0-63.9) | 49.7 (34.0-64.4) | 48.9 (32.8-63.5) | 50.1 (34.9-64.8) | 51.3 (31.6-65.9) |
| < 18 | 9177 (3.1) | 10442 (3.6) | 4716 (4.3) | 4565 (2.8) | 1161 (6.2) |
| 18-40 | 93218 (31.8) | 89971 (30.9) | 34371 (31.6) | 50145 (30.7) | 5455 (29.0) |
| 40-60 | 97569 (33.3) | 95268 (32.8) | 35715 (32.9) | 54173 (33.2) | 5380 (28.6) |
| ≥ 60 | 93325 (31.8) | 95179 (32.7) | 33823 (31.1) | 54534 (33.4) | 6822 (36.3) |
| Calendar period1 | |||||
| 2006-2009 | 59205 (20.2) | 58641 (20.2) | 22324 (20.6) | 33571 (20.5) | 2746 (14.6) |
| 2010-2020 | 234084 (79.8) | 232219 (79.8) | 86301 (79.5) | 129846 (79.5) | 16072 (85.4) |
| Educational attainment1 | |||||
| 0-9 years | 57630 (19.7) | 58420 (20.1) | 22824 (21.0) | 31452 (19.3) | 4144 (22.0) |
| 10-12 years | 134083 (45.7) | 131664 (45.3) | 49786 (45.8) | 73827 (45.2) | 8051 (42.8) |
| ≥ 13 years | 89008 (30.4) | 86096 (29.6) | 29736 (27.4) | 51397 (31.5) | 4963 (26.4) |
| Missing | 12568 (4.3) | 14680 (5.1) | 6279 (5.8) | 6741 (4.1) | 1660 (8.8) |
| IBD duration (years)1 | |||||
| mean ± SD | 10.8 ± 10.3 | 11.1 ± 10.4 | 11.9 ± 11.2 | 10.7 ± 9.6 | 9.9 ± 12.0 |
| Median (IQR) | 8.1 (2.4-16.1) | 8.4 (2.7-16.5) | 8.9 (2.8-18.1) | 8.5 (3.0-15.7) | 4.8 (0.6-15.1) |
| 0 | 26271 (9.0) | 31739 (10.9) | 12445 (11.5) | 15632 (9.6) | 3662 (19.5) |
| 0-5 | 81444 (27.8) | 70892 (24.4) | 24951 (23.0) | 40040 (24.5) | 5901 (31.4) |
| > 5 | 185574 (63.3) | 188229 (64.7) | 71229 (65.6) | 107745 (65.9) | 9255 (49.2) |
| Number of health care visits2 | |||||
| 0 | 61932 (21.1) | 63613 (21.9) | 22132 (20.4) | 37306 (22.8) | 4175 (22.2) |
| 1 | 55308 (18.9) | 55407 (19.1) | 20357 (18.7) | 32021 (19.6) | 3029 (16.1) |
| 2-3 | 71211 (24.3) | 70586 (24.3) | 25853 (23.8) | 40455 (24.8) | 4278 (22.7) |
| ≥ 4 | 104838 (35.8) | 101254 (34.8) | 40283 (37.1) | 53635 (32.8) | 7336 (39.0) |
| Disease history1 | |||||
| Hypertension | 48248 (16.5) | 46986 (16.2) | 16920 (15.6) | 26097 (16.0) | 3969 (21.1) |
| Diabetes | 20635 (7.0) | 20188 (6.9) | 6228 (5.7) | 12357 (7.6) | 1603 (8.5) |
| Obesity | 10753 (3.7) | 10531 (3.6) | 3982 (3.7) | 5671 (3.5) | 878 (4.7) |
| Dyslipidemia | 12545 (4.3) | 12076 (4.2) | 3426 (3.2) | 7671 (4.7) | 979 (5.2) |
| Chronic kidney diseases | 7353 (2.5) | 7400 (2.5) | 2937 (2.7) | 3831 (2.3) | 632 (3.4) |
| COPD | 12405 (4.2) | 12488 (4.3) | 5020 (4.6) | 6369 (3.9) | 1099 (5.8) |
- Citation: Sun JW, Li ML, Yang WS, Mårild K, Sundström J, Bergman D, Ebrahimi F, Halfvarson J, Olén O, Ludvigsson JF. Histologic remission and arrhythmias in patients with inflammatory bowel disease: A nationwide cohort study. World J Gastroenterol 2026; 32(44): 120965
- URL: https://www.wjgnet.com/1007-9327/full/v32/i44/120965.htm
- DOI: https://dx.doi.org/10.3748/wjg.120965