Pay attention to the value of liver regeneration in the re-compensation of decompensated cirrhosis

Table 1 Multidimensional assessment of cirrhosis re-compensation

Evaluate dimensions		Assessment methods
Liver histopathological evaluation	Degree of liver fibrosis	Traditional semi-quantitative scores (METAVIR, ISHAK, SCHEUER, KNODELL scores), CPA
	Hepatocyte regeneration	Platelet, AFP, precursor cell (LPCs, hematopoietic stem cells, etc.) markers
	Hepatic lobular reconstruction	Semi-quantitative assessment of pathology, GS-index
Liver function assessment	Hepatic synthesis and storage capacity	ALB, prealbumin, ALT, PT, INR, TPO, TC
	Liver biotransformation and detoxification	Bilirubin, blood ammonia, bile acids
	Hepatocyte regeneration and repair ability	Platelet, AFP, precursor cell (LPCs, hematopoietic stem cells, etc.) markers
	Common scoring models	MELD, MELD-Na, iMELD, Child-Pugh, etc.
Assessment of clinical complications		No clinical complications occur for a more extended period (at least one year) after the cause is controlled and the complications are managed

CPA: Collagen percentage area; AFP: α-fetoprotein; LPCs: Liver progenitor cells; GS-index: Glutamine synthetase index; ALB: Albumin; ALT: Alanine aminotransferase; PT: Prothrombin time; INR: International normalized ratio; TPO: Thrombopoietin; TC: Total cholesterol; MELD: Model for end-stage liver disease.