Wang JY, Yi B, Li CY, Xu HQ, Tang SH. Pay attention to the value of liver regeneration in the re-compensation of decompensated cirrhosis. World J Gastroenterol 2025; 31(24): 106564 [DOI: 10.3748/wjg.v31.i24.106564]
Corresponding Author of This Article
Shan-Hong Tang, MD, PhD, Professor, Department of Gastroenterology, Western Theater Command General Hospital, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. tangshanhong@swjtu.edu.cn
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jun 28, 2025; 31(24): 106564 Published online Jun 28, 2025. doi: 10.3748/wjg.v31.i24.106564
Pay attention to the value of liver regeneration in the re-compensation of decompensated cirrhosis
Jia-Ying Wang, Bo Yi, Chun-Yan Li, Hua-Qian Xu, Shan-Hong Tang
Jia-Ying Wang, Bo Yi, Chun-Yan Li, Hua-Qian Xu, Department of Gastroenterology, Chinese People’s Liberation Army Western Theater General Hospital, Chengdu 610083, Sichuan Province, China
Jia-Ying Wang, College of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, Sichuan Province, China
Shan-Hong Tang, Department of Gastroenterology, Western Theater Command General Hospital, Chengdu 610083, Sichuan Province, China
Co-first authors: Jia-Ying Wang and Bo Yi.
Author contributions: Wang JY wrote the manuscript; Yi B, Li CY and Xu HQ revised the manuscript; Tang SH reviewed the manuscript. All authors have reviewed and approved the final version of the manuscript. Wang JY and Yi B contributed equally to this work as co-first authors.
Conflict-of-interest statement: The authors do not choose to declare any conflict of interest related directly or indirectly to the subject of this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shan-Hong Tang, MD, PhD, Professor, Department of Gastroenterology, Western Theater Command General Hospital, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. tangshanhong@swjtu.edu.cn
Received: March 3, 2025 Revised: April 25, 2025 Accepted: June 6, 2025 Published online: June 28, 2025 Processing time: 117 Days and 16.9 Hours
Abstract
Conventional wisdom holds that progression from compensated cirrhosis to decompensated cirrhosis is irreversible in the natural history of the disease. However, in recent years, more and more clinical evidence suggests that liver cirrhosis can achieve re-compensation, that is, after effective etiological treatment and complication management, the liver function of partially decompensated patients with cirrhosis has improved and gradually stabilized, and decompensation no longer occurs for a long time. Liver regeneration, as one of the powerful intrinsic abilities of the liver, is the key to the restoration of the structure and complex physiological functions of the damaged liver. Studies have shown that the restoration of liver regeneration in patients with cirrhosis can promote the occurrence of re-compensation, thereby improving the prognosis of patients. At the same time, monitoring liver regeneration indicators is helpful in assessing patients' re-compensation potential for early selection of appropriate treatment options. Insufficient attention has been paid to the role of liver regeneration in the course of liver cirrhosis. Therefore, this article aims to review the value of liver regeneration in the re-compensation of decompensated cirrhosis.
Core Tip: Regeneration is key to the restoration of the structure and complex physiological functions of the damaged liver. When liver regeneration is stagnant, the deterioration of liver function cannot be reversed. Studies have shown that the restoration of liver regeneration in patients with cirrhosis can promote the occurrence of re-compensation, thereby improving the prognosis of patients. Therefore, we should pay attention to the value of liver regeneration in the re-compensation of decompensated patients with cirrhosis.
