Iron as a therapeutic target in chronic liver disease

Table 1 Exogenous modulators of ferroptosis

Inducers	Mechanisms	Compounds
Class 1	Inhibition of system Xc-	Erastin, sorafenib, sulfasalazin
	Prevention of cystine import	Glutamate
Class 2	Inhibition of GPX4	RLS3, DPIs (DPI7, DPI10)
Class 3	Degradation of GPX4	FIN56
	Depletion of CoQ10
Class 4	Initiation of lipid peroxidation	FINO2, PUFAs
	Indirect reduction of GPX4 activity
Inhibitors
Class 1	Suppression of iron accumulation	Deferoxamine
Class 2	Inhibition of lipid peroxidation	Ferrostatin-1, liproxstatin-1, vitamin E
Unclassified		Dynasore, probucol, selenium, nitroxide XJB-5-131
		Bicyclol, rosiglitazone

CoQ10: Coenzyme Q10; FIN: Ferroptosis inducing compounds; GPX4: Glutathione peroxidase 4; PUFAs: Polyunsaturated fatty acids.