Letter to the Editor
Copyright ©The Author(s) 2022.
World J Gastroenterol. Jul 28, 2022; 28(28): 3739-3742
Published online Jul 28, 2022. doi: 10.3748/wjg.v28.i28.3739
Table 1 Modified Naranjo score-pneumatosis intestinalis specific score
Yes/No/Do not know
Are there previous conclusive reports on this reaction?Yes1
Did the adverse event appear after the suspected drug was administered?Yes2
Did the adverse reaction improve when the drug was discontinued, or a specific antagonist was administered?Yes1
Are there alternative causes (other than the drug) that could on their own have caused the reaction?No0
Was the reaction more severe when the dose was increased or less severe when the dose was decreased?Yes1
Did the patient have a similar reaction to the same or similar drugs in any previous exposure?No0
Did any objective evidence confirm the adverse event?Yes1
Were there any symptoms or signs of abdominal pathology? (instead of isolation of drug in toxic concentrations in body fluid)No1
Were the serum inflammatory markers normal? (instead of drug rechallenge to evaluate for reoccurrence of symptoms)Yes1
Did imaging studies rule out hollow viscus perforation or inflammatory abdominal organ pathology? (instead of response to placebo administration)Yes1
Total score9 (definite)
Table 2 Interpretation of scores
Total score
Interpretation of scores
≥ 9Definite
5 to 8Probable
1 to 4Possible
≤ 0Doubtful