Evidence Review
Copyright ©The Author(s) 2021.
World J Gastroenterol. May 14, 2021; 27(18): 2054-2072
Published online May 14, 2021. doi: 10.3748/wjg.v27.i18.2054
Table 1 Changes in local flora that occur with particular esophageal disease states
Disease states
Changes in microbiome
GERDNon-erosive reflux disease: A shift towards Proteobacteria (Neisseria oralis, Moraxella spp.) and Bacteroidetes (Bacteroides uniformis, Capnocytophaga spp., and Prevotella pallens); A shift away from Fusobacteria (Leptotrichia) and Actinobacteria (Rothia spp.); Increased abundance of Dorea spp.
Reflux esophagitis: Decreased Firmicutes (Mogibacterium spp., Streptococcus infantis, Solobacterium moorei) and increased Fusobacteria (Leptotrichia spp.) and Proteobacteria (Marivita spp., Nisaea spp., Mesorhizobium spp.)
Barrett’s esophagusIncreased Fusobacteria, and Proteobacteria (Neisseria spp., and Campylobacter spp.); Decreased alpha diversity as well as Bacteroidetes and Prevotella
Esophageal adenocarcinomaIncreased abundance of Proteobacteria and decreased Firmicutes; Relatively unchanged Streptococci abundance
Eosinophilic esophagitisIncreased Proteobacteria (Neisseria and Haemophilus) and Corynebacterium; Decrease in Clostridia spp.