Modified Child-Pugh grade vs albumin-bilirubin grade for predicting prognosis of hepatocellular carcinoma patients after hepatectomy

Table 1 Modified Child-Pugh scoring system

Item	Score
	1	2	3
TBIL, µmol/L	< 34	34-51	> 51
ALB, g/L	> 35	28-35	< 28
Prothrombin time prolongation, s	< 4	4-6	> 6
PA for males, mg/L	> 190	130-190	< 130
PA for females, mg/L	> 170	120-170	< 120

MCP-1 (score = 4), MCP-2 (score = 5), and MCP-3 (score = 6).

Table 2 Baseline characteristics of the 204 patients

Variable	All patients (n = 204)
Sex (male/female)	174/30
Age, yr	52.0 ± 11.4
BMI, kg/m2	23.2 ± 3.6
Cause of hepatitis (Hepatitis B/C/Others)	174/2/28
PH (yes/no)	48/156
Liver cirrhosis (yes/no)	120/84
P grade (A/B)	187/17
BCLC stage (0 or A/B/C)	113/62/29
PA, mg/L	198.5 (149.3-238.0)
ALB, g/L	41.0 ± 4.7
TBIL, μmol/L	13.3 (9.7-18.3)
PT, s	13.7 (13.0-14.5)
ALT, U/L	36.0 (26.3-56.0)
AFP, μg/L	76.4 (9.02-1082.5)
INR	1.0 (0.98-1.1)
PLT, × 109/L	135.0 (99.8-181.0)
Number of tumors (1/2/≥3)	161/27/16
Tumor size, cm	4.0 (3.0-6.5)
PVTT (yes/no)	30/174
Capsule formation (yes/no)	27/177
Differentiation (well/poor)	81/123
Surgical bleeding, mL	300 (180-575)
Blood transfusion (yes/no)	68/136
Type of liver resection (minor/major)	159/45
Intraoperative radiotherapy and/or chemotherapy (yes/no)	148/56
ALBI grade (1/2/3)	136/66/2
MCP grade (1/2/3)	110/52/42
Overall survival time, mo	44.0 (22.0-74.0)
Recurrence-free survival time, mo	22.0 (5.0-45.0)

BMI: Body mass index; PH: Portal hypertension; C-P: Child-Pugh; BCLC: Barcelona Clinic Liver Cancer; PVTT: Portal vein tumor thrombus; MCP: Modified Child-Pugh; ALBI: Albumin-bilirubin. Type of liver resection: Minor, ≤ 3 liver segments; major, ≥ 4 liver segments. Intraoperative radiotherapy: Implanted with radiation particles I¹²⁵ or I¹³¹. Intraoperative chemotherapy: Implanted with a chemotherapy pump.

Table 3 Univariate and multivariate analyses of prognostic factors for overall survival and recurrence-free survival

Variables	Overall survival			Recurrence-free survival
	Univariate	Multivariate		Univariate	Multivariate
	P value	HR (95%CI)	P value	P value	HR (95%CI)	P value
Sex (M/F)	0.595			0.962
Age (> 50/< 50 yr)	0.020	1.853 (1.243-2.761)	0.002	0.071
BMI (≥ 24/<24 kg/m2)	0.596			0.770
Cause of hepatitis (HBV/HCV/others)	0.269			0.422
ALT (> 40/≤ 40 U/L)	0.255			0.069
AFP (≥ 400/< 400 μg/L)	0.111			0.092
INR (≥ 1.3/< 1.3)	< 0.001			0.009
PLT (≥ 100/< 100 × 109/L)	0.392			0.713
Number of tumors (single/≥ 2)	0.243			0.065
Tumor size (≥ 5/< 5 cm)	< 0.001			< 0.001
Blood transfusion (yes/no)	0.001			0.003
Surgical bleeding (> 400/≤ 400 mL)	0.005			0.003	1.437 (1.004-2.058)	0.048
Types of liver resection (minor/major)	< 0.001			< 0.001
Intraoperative radiotherapy and/or chemotherapy (yes/no)	0.649			0.430
PVTT (yes/no)	< 0.001			0.005
Capsule formation (yes/no)	0.408			0.374
Differentiation (good/poor)	0.004	2.230 (1.452-3.426)	< 0.001	0.029
PH (yes/no)	0.809			0.542
Liver cirrhosis (yes/no)	0.944			0.896
Child-Pugh grade (A/B)	< 0.001			0.001
BCLC stage (0 or A/B/C)	< 0.001			< 0.001
0 or A		1			1
B		2.635 (1.235-5.622)	0.012		2.246 (1.095-4.607)	0.027
ALBI grade (1/2/3)	< 0.001			0.003
MCP grade	< 0.001			< 0.001
1		1			1
2		1.864 (1.174-2.959)	0.008		1.830 (1.246-2.687)	0.002
3		2.005 (1.071-3.753)	0.030

BMI: Body mass index; PH: Portal hypertension; C-P: Child-Pugh; BCLC: Barcelona Clinic Liver Cancer; PVTT: Portal vein tumor thrombus; ALBI: Albumin-Bilirubin; MCP: Modified Child-Pugh. Type of liver resection: Minor, ≤ 3 liver segments; major, ≥ 4 liver segments. Intraoperative radiotherapy: Implanted with radiation particles I¹²⁵ or I¹³¹. Intraoperative chemotherapy: Implanted with a chemotherapy pump.