Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients

Table 1 Demographic characteristics

	Control, n = 15	ICP, n = 15	Adjusted P value
Age in yr	30.0 (28.5-32.0)	31.0 (30.5-32.5)	0.3322
Pregnancy in d	266.0 (248.0-274.5)	234.0 (227.5-252.0)	0.0273
Alanine aminotransferase in U/L	12.0 (8.5-17.0)	22.0 (12.0-50.0)	0.0369
Aspartate aminotransferase in U/L	16.0 (14.0-18.5)	29.0 (19.5-41.5)	0.0273
Lactate dehydrogenase in U/L	177.0 (155.0-217.5)	208.0 (191.0-217.5)	0.2196
Total bilirubin in μmol/L	7.1 (6.1-7.9)	6.4 (5.9-9.6)	0.8356
Direct bilirubin in μmol/L	1.7 (1.2-1.8)	2.5 (1.6-3.0)	0.2669
Total bile acids in μmol/L	4.0 (3.5-5.5)	26.0 (18.5-38.0)	0.0000
Urea in mmol/L	3.8 (3.5-4.0)	3.9 (3.1-5.0)	0.6321
Creatinine in μmol/L	42.0 (39.0-44.5)	48.0 (44.0-54.0)	0.0463
Uric acid in μmol/L	294.0 (253.0-342.0)	261.0 (236.5-333.0)	0.4552

Continuous data are presented as median and interquartile range in squared parentheses and were tested using the Mann-Whitney U test. P < 0.05 was considered statically significant. The adjusted P value was calculated by the “p.adjust ()” command in R using the “BH” method to control for the false discovery rate. ICP: Intrahepatic cholestasis in pregnancy.